Celi A, Lorenzet R, Furie B, Furie B C
U.O. Fisiopatologia Respiratoria, Dipartimento di Cardiologia, Angiologia e Pneumologia dell'Università, Pisa, Italy.
Semin Hematol. 1997 Oct;34(4):327-35.
Leukocytes, platelets, and endothelial cells interact at sites of vascular injury and inflammation through adhesion receptors on the cell surface. On binding of ligand to receptor, these receptors initiate intracellular signaling that leads to the modulation of several biological properties of the cells involved. These finely regulated processes involve several classes of cell adhesion molecules: integrins, immunoglobulin-like proteins, selectins, and mucin-like proteins as well as an array of soluble mediators. Interaction of these cell adhesion molecules serves to recruit circulating cells to the blood vessel endothelium or to accumulated platelets on the vessel wall and to foster cell-cell communication. The importance of these interactions to inflammation, blood coagulation, and the immune response is outlined.
白细胞、血小板和内皮细胞通过细胞表面的黏附受体在血管损伤和炎症部位相互作用。当配体与受体结合时，这些受体启动细胞内信号传导，从而导致所涉及细胞的几种生物学特性发生调节。这些精细调控的过程涉及几类细胞黏附分子：整合素、免疫球蛋白样蛋白、选择素和黏蛋白样蛋白以及一系列可溶性介质。这些细胞黏附分子的相互作用有助于将循环细胞募集到血管内皮或血管壁上聚集的血小板处，并促进细胞间通讯。概述了这些相互作用对炎症、血液凝固和免疫反应的重要性。
