Frolova L E, Morozova L V, Dia Ch K
Stomatologiia (Mosk). 1993 Jul-Sep;72(3):66-9.
Clinico-microbiologic examinations of 153 children with cleft palate aged 2 to 9 were carried out. Two groups of patients with different pattern of operative wound healing after uranoplasty were singled out: 110 ones with primary healing and 13 ones with infectious inflammations of the wound. The incidence of S. aureus carriership on the palatal mucosa before surgery was higher among patients who developed postoperative inflammations. On day 3 after the operation gram-negative bacilli were isolated from the majority of patients with postoperative wound inflammations coursing in the presence of marked dysbacteriosis as against patients in whom the wounds healed by primary intention. The authors suggest a method for wound infection prevention in uranoplasty, consisting in irrigation of the operative wound with acilact (a biopreparation) suspension and shortening of antibiotic prevention course to just 48-72 h; the efficacy of this method was confirmed by a reduction of the incidence of postoperative complications. Normal microflora representatives predominated in the microbiocenosis of the operative wound on days 3 and 10-12 after uranoplasty.
对153名2至9岁的腭裂患儿进行了临床微生物学检查。挑选出两组腭裂修复术后手术伤口愈合模式不同的患者：110例一期愈合患者和13例伤口感染发炎患者。术后发生炎症的患者术前腭黏膜上金黄色葡萄球菌带菌率更高。术后第3天，在术后伤口发炎且存在明显菌群失调的大多数患者中分离出革兰氏阴性杆菌，而伤口一期愈合的患者则不然。作者提出了一种腭裂修复术中预防伤口感染的方法，即使用嗜酸乳杆菌（一种生物制剂）悬浮液冲洗手术伤口，并将抗生素预防疗程缩短至仅48 - 72小时；术后并发症发生率的降低证实了该方法的有效性。腭裂修复术后第3天以及第10 - 12天，手术伤口微生物群落中正常微生物群代表占主导地位。
