García-Martínez C, Reyes-López J, Joseph-Nathan P
Departamento de Química Orgánica, Centro de Investigación, Científica de Yucatán A.C., México.
Steroids. 1993 Sep;58(9):396-9. doi: 10.1016/0039-128x(93)90077-z.
A three-step synthesis of 16-methylene-17 alpha-hydroxypregna-1,4,9(11)- triene-3,20-dione, which has been previously obtained by microbial transformation, was achieved from 3 beta-hydroxy-16 alpha, 17-epoxy-16 beta-methyl-5 alpha-pregn-9(11)-en-20-one in an overall yield of 35%. All compounds involved in the process were characterized spectroscopically and their 13C NMR shielding effects are briefly discussed.
16-亚甲基-17α-羟基孕甾-1,4,9(11)-三烯-3,20-二酮先前是通过微生物转化获得的，现在从3β-羟基-16α,17-环氧-16β-甲基-5α-孕甾-9(11)-烯-20-酮出发，经过三步合成得到了该产物，总产率为35%。对该过程中涉及的所有化合物进行了光谱表征，并简要讨论了它们的13C NMR屏蔽效应。
