Johnson E S, Seely J H, White W F, DeSombre E R
Science. 1976 Oct 15;194(4262):329-30. doi: 10.1126/science.823643.
Long-term administration of [D-Leu6, des-Gly-NH210, Pro-ethylamide9]-GnRH, an analog of gonadotropin releasing hormone, caused regression of neoplastic tissue in a rat bearing a spontaneous mammary adenocarcinoma and in rats in which tumors had been induced by treatment with dimethylbenzanthracene (DMBA). During two separate treatment periods with the analog, the tumor in the single animal regressed although it had previously grown spontaneously. After a third period of growth, ovariectomy also induced regression, suggesting endocrine dependency of the tumor. These observations were confirmed in the DMBA-induced tumor system, where tumor regression in the analog-treated rats was comparable to that observed in the ovariectomized rats, and in both cases the tumor regression was significant when compared to untreated controls.
长期给予促性腺激素释放激素类似物[D-亮氨酸6，去甘氨酰胺10，脯氨酸乙酯9]-GnRH，可使自发乳腺腺癌大鼠以及经二甲基苯并蒽（DMBA）诱导产生肿瘤的大鼠体内的肿瘤组织消退。在对该类似物进行的两个独立治疗期内，单只动物体内先前自发生长的肿瘤出现了消退。在第三个生长阶段后，卵巢切除术也诱导肿瘤消退，提示该肿瘤具有内分泌依赖性。这些观察结果在DMBA诱导的肿瘤模型中得到了证实，在该模型中，接受类似物治疗的大鼠的肿瘤消退情况与卵巢切除大鼠相当，并且与未治疗的对照组相比，两种情况下的肿瘤消退均很显著。
