Atlihan F, Karakaş Z, Batun S
Department of Pediatrics, Dicle University Faculty of Medicine, Diyarbakir.
Turk J Pediatr. 1993 Jan-Mar;35(1):45-51.
In this study Protein C (PC) and antithrombin III (AT III) levels in childhood acute leukemia were investigated. The mean PC activity levels in 19 newly diagnosed cases of acute leukemia were significantly lower as compared with the normal controls (p < 0.05). A significant increase was found (p < 0.01) in the patients in remission. Prior to treatment 78.8 percent of patients had decreased PC activity levels, but all patients had normal PC activity during remission. Decreased PC activity levels were found to be independent of the leukocyte count and liver function. No statistically significant difference was found in the AT III antigen levels between the untreated patients, the patients in remission and the control group. Our results indicate that apart from thrombocytopenia, low PC activity levels and alterations in fibrinolysis and coagulation may be responsible for the hemorrhagic manifestations observed in cases of acute leukemia.
本研究对儿童急性白血病患者的蛋白C（PC）和抗凝血酶III（AT III）水平进行了调查。19例新诊断的急性白血病患者的平均PC活性水平与正常对照组相比显著降低（p < 0.05）。缓解期患者的PC活性水平显著升高（p < 0.01）。治疗前，78.8%的患者PC活性水平降低，但所有患者在缓解期PC活性均正常。发现PC活性水平降低与白细胞计数和肝功能无关。未治疗患者、缓解期患者和对照组之间的AT III抗原水平无统计学显著差异。我们的结果表明，除血小板减少外，低PC活性水平以及纤维蛋白溶解和凝血功能改变可能是急性白血病患者出血表现的原因。
