Sedovic M, Nagy O, Slanina L
Ustav experimentálnej veterinárnej medicíny, Kosice.
Vet Med (Praha). 1993;38(8):467-75.
When examining diseased calves, sporadically pronounced haemoglobinuria with dark red urine can be observed. In serious cases the clinical picture may be manifold but peculiar; in easy cases, however, when there are no distinct clinical symptoms, a larger scale of examinations is needed to aid differential diagnosis. Eight roughage-fed bulls aged two months, weighing 55-71 kg were used in this experiment. Selected biochemical indices of the mineral, enzymatic, hepatic, energetic and urinary profile were determined in the blood serum and urine of the animals. After the administration of cold water at an amount representing 12% of the animal's body weight, ionogram values were determined. In all indices a positive correlation with hydraemia and a decrease in Na, Cl, Ca, Mg and P levels were observed. Correction of the above levels occurred within 24 hours, with the exception of Na and P concentrations that did not reach starting values. As to the enzymatic profile (AST, ALT, GGT), no pronounced disturbances could be observed. The most profound changes were seen in AST activity that increased in the 5th hour of the experiment. A slight tendency towards hypoproteinaemia was observed to continue even in 24 hours. Hypoglobulinaemia reached its starting value in the 24th hour while simultaneously albumin levels slightly increased. The increasing bilirubin levels reached their maximum in the 5th and 6th hour; correction of the former occurred within 24 hours. The urinary profile revealed polyuria, aciduria, aquaeous urine and haemoglobinuria, the latter reaching its peak between hours 1 and 3 following water administration.(ABSTRACT TRUNCATED AT 250 WORDS)
检查患病小牛时，偶尔会观察到尿液呈深红色且伴有明显血红蛋白尿。严重情况下，临床表现可能多种多样且较为特殊；然而在轻症病例中，当没有明显临床症状时，则需要进行更广泛的检查以辅助鉴别诊断。本实验选用了8头两个月大、体重55 - 71千克、以粗饲料喂养的公牛。测定了这些动物血清和尿液中矿物质、酶、肝脏、能量及尿液相关的选定生化指标。给动物灌服相当于其体重12%的冷水后，测定离子图值。在所有指标中，均观察到与血液稀释呈正相关，且钠、氯、钙、镁和磷水平降低。上述水平在24小时内得到纠正，但钠和磷浓度未恢复到初始值。至于酶谱（AST、ALT、GGT），未观察到明显紊乱。实验第5小时，AST活性变化最为显著，呈上升趋势。即使在24小时时，仍观察到轻微的低蛋白血症倾向。低球蛋白血症在第24小时恢复到初始值，同时白蛋白水平略有升高。胆红素水平升高在第5和第6小时达到峰值，前者在24小时内得到纠正。尿液检查显示多尿、酸尿、水样尿和血红蛋白尿，后者在灌服水后1至3小时达到峰值。（摘要截断于250字）
