Frederiksen P, Thommesen P, Kjaer T B, Bichel P
Acta Pathol Microbiol Scand A. 1978 Nov;86A(6):461-4. doi: 10.1111/j.1699-0463.1978.tb02070.x.
Transrectal fine needle aspiration biopsy was carried out in 59 patients with cancer of the prostate, benign prostatic hypertrophy and prostatis for cytomorphological examination and flow cytometric DNA analysis. One major single peak in the DNA histogram was observed in patients with benign hyperplasia, prostatitis and in some patients with carcinoma. A DNA histogram with a second or third peak was always compatible with carcinoma and was found both in patients with carcinoma in stage I--II and stage III--IV. It is suggested that patients with hyperploid cancers in stage I--II could benefit from early treatment.
对59例前列腺癌、良性前列腺增生和前列腺炎患者进行经直肠细针穿刺活检，以进行细胞形态学检查和流式细胞术DNA分析。在良性增生、前列腺炎患者以及部分前列腺癌患者的DNA直方图中观察到一个主要的单峰。出现第二个或第三个峰的DNA直方图总是与前列腺癌相符，在Ⅰ - Ⅱ期和Ⅲ - Ⅳ期前列腺癌患者中均有发现。提示Ⅰ - Ⅱ期超二倍体癌患者可能从早期治疗中获益。
