年龄和性别在喂食3'-甲基-4-二甲基氨基偶氮苯的大鼠慢性甲状腺炎中的作用。
Role of age and sex in chronic thyroiditis in rats fed 3'-methyl-4-dimethylaminoazobenzene.
作者信息
Reuber M D, Glover E L
出版信息
Vet Pathol. 1976;13(4):295-302. doi: 10.1177/030098587601300406.
PMID:823690
Abstract
Inbred male and female Buffalo strain rats were started at 4, 8, 12, 24, or 52 weeks of age on 0.06% 3'-methyl-4-dimethylaminoazobenzene in a low-protein, choline-deficient diet. Eight-week-old males and females were the most susceptible to the development of chronic thyroiditis, but females were more susceptible than the males. Female rats of other ages developed a slightly higher incidence of thyroiditis than the male rats, the difference being most noticeable for rats 12 weeks old.
摘要
近交系雄性和雌性布法罗品系大鼠在4周、8周、12周、24周或52周龄时开始食用含0.06% 3'-甲基-4-二甲基氨基偶氮苯的低蛋白、胆碱缺乏饮食。8周龄的雄性和雌性大鼠最易患慢性甲状腺炎，但雌性比雄性更易患病。其他年龄的雌性大鼠甲状腺炎发病率略高于雄性大鼠，这种差异在12周龄的大鼠中最为明显。
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