Cohen S B, Weetman A P
University of Cambridge, Department of Medicine, United Kingdom.
J Endocrinol Invest. 1988 Sep;11(8):625-7. doi: 10.1007/BF03350197.
We have investigated the effect of excess iodide alone, following iodide depletion or in conjunction with a mild thyroid insult (trypan blue) in Buffalo strain rats, which are genetically susceptible to experimental autoimmune thyroiditis. In all three cases a high iodine diet led to enhanced thyroglobulin antibody production, usually accompanied by worsening of the severity of thyroiditis. Moreover, the administration of a normal iodine diet after iodide depletion resulted in thyroglobulin antibody formation. These results provide further support for a role for dietary iodine in modulating experimental autoimmune thyroiditis with implications for human thyroid autoimmunity.
我们研究了在布法罗品系大鼠中，单独给予过量碘、碘耗竭后给予过量碘或与轻度甲状腺损伤（台盼蓝）联合使用过量碘的效果，布法罗品系大鼠对实验性自身免疫性甲状腺炎具有遗传易感性。在所有这三种情况下，高碘饮食都会导致甲状腺球蛋白抗体产生增加，通常伴随着甲状腺炎严重程度的加重。此外，碘耗竭后给予正常碘饮食会导致甲状腺球蛋白抗体形成。这些结果进一步支持了膳食碘在调节实验性自身免疫性甲状腺炎中的作用，这对人类甲状腺自身免疫性疾病具有启示意义。
