Pereboeva L A, Tkachev V K, Kolesnikova L V, Krendeleva L Ia, Riabchikova E I, Smolina M P
Vopr Virusol. 1993 Jul-Aug;38(4):179-82.
Morphological study of internal organs of guinea pigs inoculated with Ebola virus at 2-8 passages was carried out. In the course of these passages the number of infected cells and virus particles in the organs was shown to increase, and the destructive changes in organs became more pronounced. In the 1st-3rd passages Ebola virus replication was observed in macrophagal cells only but beginning from the 4th passage of virus reproduction was found also in hepatocytes, spongiocytes, and fibroblasts.
对接种了2 - 8代埃博拉病毒的豚鼠内脏器官进行了形态学研究。在这些传代过程中，器官中受感染细胞和病毒颗粒的数量显示出增加，并且器官中的破坏性变化变得更加明显。在第1 - 3代传代中，仅在巨噬细胞中观察到埃博拉病毒复制，但从第4代开始，在肝细胞、神经胶质细胞和成纤维细胞中也发现了病毒繁殖。
