Dadaeva A A, Sizikova L P, Subbotina E L, Chepurnov A A
Vopr Virusol. 2006 Jul-Aug;51(4):32-7.
The trend in hematological and immunological parameters during Ebola virus passages in guinea-pigs indicated that pathophysiological changes occurred just during the second passage and further became stronger. The increase of some parameters and their correlation with the occurrence of fatal outcomes allowed the authors to reveal the most significant changes as increased juvenile platelets, whole blood virus appearance, higher echinocytes, a rise in the pro mil of blast cells and megakaryocytes in the bone marrow, and decreased neutrophilic phagocytic activity. Viral acquisition of the properties of lethality to guinea-pigs depends on the fine mechanisms responsible for viral interaction with host cells, which may lead to viral genetic changes during passages.
埃博拉病毒在豚鼠体内传代过程中血液学和免疫学参数的变化趋势表明，病理生理变化仅在第二次传代时出现，并进一步加剧。一些参数的增加及其与致命结果发生的相关性使作者能够揭示最显著的变化，如幼年血小板增加、全血中病毒出现、棘红细胞增多、骨髓中原始细胞和巨核细胞的千分率升高以及中性粒细胞吞噬活性降低。病毒获得对豚鼠的致死特性取决于负责病毒与宿主细胞相互作用的精细机制，这可能导致传代过程中病毒基因发生变化。
