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胎儿组织移植的伦理问题。

Ethics of fetal tissue transplantation.

作者信息

Sanders L M, Giudice L, Raffin T A

机构信息

Stanford University Center for Biomedical Ethics, Stanford University School of Medicine, California 94305-5236.

出版信息

West J Med. 1993 Sep;159(3):400-7.

PMID:8236984
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1011357/
Abstract

Now that the Clinton Administration has overturned the ban on federal funding for fetal tissue transplantation, old ethical issues renew their relevance and new ethical issues arise. Is fetal tissue transplantation necessary and beneficial? Are fetal rights violated by the use of fetal tissue in research? Is there a moral danger that the potential of fetal tissue donation will encourage elective abortions? Should pregnant women be allowed to designate specific fetal transplant recipients? What criteria should be used to select fetal tissue transplants? Whose consent should be required for the use of fetal tissue for transplantation? We review the current state of clinical research with fetal tissue transplantation, the legal history of fetal tissue research, the major arguments against the use of fetal tissue for transplantation, and the new postmoratorium ethical dilemmas. We include recommendations for guidelines to govern the medical treatment of fetal tissue in transplantation.

摘要

既然克林顿政府已经推翻了禁止联邦政府为胎儿组织移植提供资金的禁令,旧的伦理问题重新具有相关性,新的伦理问题也随之出现。胎儿组织移植是否必要且有益?在研究中使用胎儿组织是否侵犯了胎儿权利?胎儿组织捐赠的可能性是否存在道德风险,会鼓励选择性堕胎?应该允许孕妇指定特定的胎儿移植接受者吗?应该使用什么标准来选择胎儿组织移植?使用胎儿组织进行移植需要谁的同意?我们回顾了胎儿组织移植临床研究的现状、胎儿组织研究的法律历史、反对使用胎儿组织进行移植的主要论点,以及禁令解除后的新伦理困境。我们还包括了关于规范移植中胎儿组织医学处理的指导方针的建议。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c874/1011357/5def443bc637/westjmed00073-0170-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c874/1011357/5def443bc637/westjmed00073-0170-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c874/1011357/5def443bc637/westjmed00073-0170-a.jpg

相似文献

1
Ethics of fetal tissue transplantation.胎儿组织移植的伦理问题。
West J Med. 1993 Sep;159(3):400-7.
2
Bioethical catch-22: the moratorium on federal funding of fetal tissue transplantation research and the NIH revitalization amendments.生物伦理困境:联邦政府对胎儿组织移植研究的资金冻结与国立卫生研究院振兴修正案
J Contemp Health Law Policy. 1993 Spring;9:485-519.
3
Ethical issues surrounding the transplantation of human fetal tissues.围绕人类胎儿组织移植的伦理问题。
Clin Res. 1992 Dec;40(4):661-6.
4
Conceiving to abort and donate fetal tissue: new ethical strains in the transplantation field -- a survey of existing law and a proposal for change.怀着堕胎并捐赠胎儿组织的意图:移植领域新出现的伦理问题——对现行法律的调查及变革建议
UCLA Law Rev. 1989;36(6):1167-205.
5
Fetal tissue transplantation: regulating the medical hope for the future.胎儿组织移植:规范未来的医学希望。
J Law Health. 1989;4(1):57-81.
6
Restricting donative choice: fetal tissue transplantation and respect for human life.限制捐赠选择:胎儿组织移植与对人类生命的尊重
J Law Health. 1995;10(2):259-85.
7
Fetal tissue transplants: restricting recipient designation.胎儿组织移植:限制受体指定
Hastings Law J. 1988 Jul;39(5):1079-107.
8
Abortion to obtain fetal tissue for transplant.为获取用于移植的胎儿组织而进行的堕胎。
Suffolk Univ Law Rev. 1993 Winter;27(4):1359-89.
9
Fetal tissue research and the misread compromise.胎儿组织研究与被误解的妥协。
Hastings Cent Rep. 1991 Sep-Oct;21(5):7-12.
10
The ethical options in transplanting fetal tissue.
Hastings Cent Rep. 1987 Feb;17(1):9-15.

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Long-Term Evaluation of Intranigral Transplantation of Human iPSC-Derived Dopamine Neurons in a Parkinson's Disease Mouse Model.人诱导多能干细胞源性多巴胺神经元脑内移植治疗帕金森病模型的长期评估
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Holistic Approach of Swiss Fetal Progenitor Cell Banking: Optimizing Safe and Sustainable Substrates for Regenerative Medicine and Biotechnology.

本文引用的文献

1
With fetal tissue moratorium lifted, applications begin reaching National Institutes of Health.随着胎儿组织研究禁令的解除,相关申请开始送达美国国立卫生研究院。
JAMA. 1993 Mar 3;269(9):1086. doi: 10.1001/jama.1993.03500090018005.
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Parkinson's disease. Fetal implants put to the test.帕金森病。胎儿植入物接受测试。
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瑞士胎儿祖细胞库的整体方法:为再生医学和生物技术优化安全且可持续的基质。
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The use of adrenal medullary and fetal grafts as a treatment for Parkinson disease.使用肾上腺髓质和胎儿移植物治疗帕金森病。
N Y State J Med. 1988 Jun;88(6):287-9.
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Genug ist genug: a fetus is not a kidney.够了就是够了:胎儿不是肾脏。
Hastings Cent Rep. 1988 Dec;18(6):13-9.
6
The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function.严重联合免疫缺陷-人源化小鼠:用于分析人类血液淋巴细胞分化与功能的小鼠模型。
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Multicenter study of autologous adrenal medullary transplantation to the corpus striatum in patients with advanced Parkinson's disease.晚期帕金森病患者自体肾上腺髓质移植至纹状体的多中心研究。
N Engl J Med. 1989 Feb 9;320(6):337-41. doi: 10.1056/NEJM198902093200601.
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In-utero transplantation of fetal liver haemopoietic stem cells in monkeys.
Lancet. 1989 Dec 16;2(8677):1425-7. doi: 10.1016/s0140-6736(89)92036-9.
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In-utero transplantation of stem cells in bare lymphocyte syndrome.裸淋巴细胞综合征中的干细胞宫内移植。
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