Sasaki H, Meguro K, Matsuzaki Y, Doi C, Yamaguchi S, Nakamura T, Aoki T, Sekizawa K, Shimizu Y
Department of Geriatric Medicine, Tohoku University School of Medicine, Sendai, Japan.
Yakubutsu Seishin Kodo. 1993 Jun;13(3):143-7.
The effect of nicotine on learning disturbance was tested in rats fed with a choline-deficient diet (Ch free) or in senescence-accelerated mice (SAM). Concentration of acetylcholine in the brain was significantly lower in rats fed with Ch free and SAM. Passive avoidance learning shows that rats fed with Ch free and SAM showed significantly impaired learning, compared to controls. Nicotine (0.04 mg/kg) administered intraperitonealy significantly improved learning in animals with learning disturbances, as well as in controls. Vitamin B12 facilitated acetylcholine synthesis or release in the brain and improved the cognitive disturbance. We therefore suggest that acetylcholine contributes to learning and that nicotine may improve learning in an acetylcholine deprived rats.
在喂食胆碱缺乏饮食（无胆碱）的大鼠或加速衰老小鼠（SAM）中测试了尼古丁对学习障碍的影响。喂食无胆碱饮食的大鼠和SAM小鼠大脑中的乙酰胆碱浓度显著降低。被动回避学习表明，与对照组相比，喂食无胆碱饮食的大鼠和SAM小鼠的学习能力显著受损。腹腔注射尼古丁（0.04毫克/千克）可显著改善有学习障碍的动物以及对照组的学习能力。维生素B12促进大脑中乙酰胆碱的合成或释放，并改善认知障碍。因此，我们认为乙酰胆碱有助于学习，尼古丁可能改善乙酰胆碱缺乏大鼠的学习能力。
