Sluijmer A V, Heineman M J, Evers J L, de Jong F H
Department of Obstetrics and Gynaecology, De Wever Hospital, Heerlen, The Netherlands.
Acta Endocrinol (Copenh). 1993 Oct;129(4):311-4. doi: 10.1530/acta.0.1290311.
In a patient with a granulosa cell tumour, stage 1a1, peripheral and ovarian vein blood samples were drawn before, during and after bilateral oophorectomy. Before operation inhibin and follicle-stimulating hormone levels were in the premenopausal range, whereas the peripheral level of oestradiol and luteinizing hormone were in the normal postmenopausal range. In the ovarian vein at the side of the tumour, inhibin and oestradiol levels were elevated, whereas in the contralateral ovarian vein the concentrations of inhibin and oestradiol were in the same range as in the peripheral vein. Immunoreactive inhibin levels in the homogenized tumour were 23 times higher than in the contralateral ovary, whereas inhibin bioactivities in the same samples amounted to 126 and 14 U/mg protein, respectively. After removal of the tumour, peripheral serum follicle-stimulating hormone and inhibin levels were in the normal postmenopausal range again. We conclude that inhibin can have a role as a marker for granulosa cell tumours.
在一名患有1a1期颗粒细胞瘤的患者中，在双侧卵巢切除术之前、术中及术后采集了外周血和卵巢静脉血样本。手术前，抑制素和促卵泡生成素水平处于绝经前范围，而外周雌二醇和促黄体生成素水平处于绝经后正常范围。在肿瘤侧的卵巢静脉中，抑制素和雌二醇水平升高，而在对侧卵巢静脉中，抑制素和雌二醇浓度与外周静脉中的浓度处于同一范围。肿瘤匀浆中的免疫反应性抑制素水平比同侧卵巢高23倍，而相同样本中的抑制素生物活性分别为126和14 U/mg蛋白质。切除肿瘤后，外周血清促卵泡生成素和抑制素水平再次处于绝经后正常范围。我们得出结论，抑制素可作为颗粒细胞瘤的标志物。
