Lappöhn R E, Burger H G, Bouma J, Bangah M, Krans M
Department of Obstetrics and Gynecology, Groningen State University Hospital, The Netherlands.
Acta Obstet Gynecol Scand Suppl. 1992;155:61-5. doi: 10.1111/j.1600-0412.1992.tb00008.x.
In order to determine whether serum-immunoreactive inhibin could constitute a biochemical marker for the presence and progression of ovarian granulosa cell tumors and their metastases, we measured immunoreactive inhibin concentrations in series of serum samples obtained from 8 patients with granulosa cell tumor. Six series were tested in retrospect. From these, three came from patients who had been treated with an abdominal hysterectomy and bilateral salpingo-oophorectomy. In the 2 patients with residual or recurrent disease, inhibin was elevated, 4 and 20 months respectively before clinical manifestations of recurrence became evident; it reflected the effects of secondary therapy. Inhibin remained undetectable in one patient who was free of disease during 11 years of follow-up. Inhibin concentrations were also inappropriately increased in 2 of 3 women with amenorrhea and infertility resulting from small granulosa cell tumors. After removal, inhibin concentrations became normal and fertility resumed. Fertility also returned in the third patient. There was a significant negative correlation between the serum inhibin and FSH concentrations, consistent with autonomous production of inhibin by granulosa cell tumors. It is concluded that granulosa cell tumors have the capacity to produce inhibin. In retrospect, inhibin proved to be a marker for both primary and also recurrent and residual disease.
为了确定血清免疫反应性抑制素是否可作为卵巢颗粒细胞瘤及其转移灶存在和进展的生化标志物，我们检测了8例颗粒细胞瘤患者系列血清样本中的免疫反应性抑制素浓度。对6个系列进行了回顾性检测。其中，3个系列来自接受腹部子宫切除术和双侧输卵管卵巢切除术治疗的患者。在2例有残留或复发病灶的患者中，抑制素升高，分别在复发临床表现明显前4个月和20个月；这反映了二次治疗的效果。在1例随访11年无疾病的患者中，抑制素仍未检测到。3例因小颗粒细胞瘤导致闭经和不孕的女性中，有2例抑制素浓度也异常升高。切除肿瘤后，抑制素浓度恢复正常，生育能力恢复。第3例患者的生育能力也恢复了。血清抑制素与促卵泡生成素浓度之间存在显著负相关，这与颗粒细胞瘤自主分泌抑制素一致。结论是颗粒细胞瘤有产生抑制素的能力。回顾性研究表明，抑制素是原发性、复发性和残留性疾病的标志物。
