Yoto Y, Kudoh T, Suzuki N, Matsunaga Y, Chiba S
Department of Pediatrics, School of Medicine, Sapporo Medical University, Japan.
Acta Haematol. 1993;90(1):8-12. doi: 10.1159/000204365.
Human parvovirus B19 (B19) is a known cause of erythema infectiosum (fifth disease) and aplastic crisis in patients with hemolytic anemias. When patients with malignant diseases are infected by B19 during chemotherapy, erythroid suppression of bone marrow sometimes occurs. We performed a retrospective investigation of B19 infection among 95 children with malignant diseases in our hospital during the past 14 years. By the method of dot blot hybridization, 9 of 95 patients were found to be positive for B19 DNA during chemotherapy. All 9 patients had reticulocytopenia at the time B19 DNA was detected in their serum samples. Neutropenia and thrombocytopenia were not found. Seven of them had only transient reticulocytopenia. Serum samples from 2 other patients were positive for B19 DNA for a longer time. They suffered from persistent anemia for about 2 and 13 month, respectively. The years when B19 DNA was detected from the 9 patients corresponded to the prevalence of erythema infectiosum in Japan.
人类细小病毒B19（B19）是传染性红斑（第五病）和溶血性贫血患者再生障碍危象的已知病因。恶性疾病患者在化疗期间感染B19时，有时会发生骨髓红系抑制。我们对我院过去14年中95例恶性疾病患儿的B19感染情况进行了回顾性调查。通过斑点杂交法，在95例患者中有9例在化疗期间B19 DNA检测呈阳性。在其血清样本中检测到B19 DNA时，所有9例患者均有网织红细胞减少。未发现中性粒细胞减少和血小板减少。其中7例仅有短暂的网织红细胞减少。另外2例患者的血清样本B19 DNA阳性持续时间较长。他们分别患有持续性贫血约2个月和13个月。从这9例患者中检测到B19 DNA的年份与日本传染性红斑的流行情况相符。
