Guieu R, Harley J R, Blin O, Pouget J, Serratrice G
Clinique des Maladies du Système Nerveux et de l'Appareil Locomoteur, CHU Timone, Marseille, France.
Acta Neurol (Napoli). 1993 Jun;15(3):183-8.
The purpose of this study was to measure the nociceptive threshold in hypothyroid patients by determining when the nociceptive flexion reflex of the lower limb occurs under percutaneous electrical stimulation of the sural nerve, given that this threshold is well correlated with pain sensation. Twelve hypothyroid patients and twelve control subjects participated in the study. In the case of the hypothyroid patients, the nociceptive flexion reflex (or RIII reflex) was measured before and six weeks after the onset of substitution treatment. The results clearly indicate that the nociceptive threshold of the patients with hypothyroidism was significantly higher than that of the control subjects. After six weeks of substitution treatment, the RII threshold return to normal. The analgesia observed in the hypothyroid patients in this study do not appear to be correlated with the blood TSH level. The possible mechanisms of these analgesic effects are discussed.
本研究的目的是通过确定在腓肠神经经皮电刺激下下肢伤害性屈曲反射出现的时间来测量甲状腺功能减退患者的伤害性阈值，因为该阈值与疼痛感觉密切相关。12名甲状腺功能减退患者和12名对照受试者参与了该研究。对于甲状腺功能减退患者，在替代治疗开始前和开始六周后测量伤害性屈曲反射（或RIII反射）。结果清楚地表明，甲状腺功能减退患者的伤害性阈值明显高于对照受试者。经过六周的替代治疗后，RII阈值恢复正常。本研究中在甲状腺功能减退患者中观察到的镇痛作用似乎与血液TSH水平无关。讨论了这些镇痛作用的可能机制。
