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[大鼠下丘脑、神经垂体、肾上腺和腮腺中非特异性酯酶对抑制剂的组织化学行为研究]

[A contribution of the histochemical behaviour of the unspecific esterases in hypothalamus, neurohypophysis, adrenal and parotid gland of the rat against inhibitors].

作者信息

Marciniak C

出版信息

Acta Histochem. 1976;55(2):187-207. doi: 10.1016/S0065-1281(76)80072-4.

Abstract

On continuation of study by KURZ and GOSLAR (1974) concerning the inhibitory effects to non specific esterases on liver and kidney, the behaviour of alpha-naphthyl-acetate-esterases on hypothalamus, neurohypophysis, adrenal and parotid glands of rats had been examined against aldehydes, organic solution-mediators and anorganic salts. It had shown a different sensitiveness, the esterases of tanycytes, nerve cells and pituicytes acted more sensitive than those of the adrenal cortex and parotid gland. The differences seen on the solution-mediators were less; on metal salts from different groups of periodical system which applied, the most intense blocking effect was found in the nerve cells. The esterases of tanycytes and the immediately extensively reacting pituicytes, as well as the adrenal cortex esterases reacted essentially less sensitive, the gland cells of parotid even almost not at all. The arguments of this behaviour are discussed and pointed out with different complexity of alpha-naphthylacetate splitting enzymes on individual organs.

摘要

在库尔兹和戈斯拉尔(1974年)关于肝脏和肾脏中非特异性酯酶抑制作用的研究继续进行的过程中,针对醛类、有机溶液介质和无机盐,检测了大鼠下丘脑、神经垂体、肾上腺和腮腺中α-萘乙酸酯酶的行为。结果显示出不同的敏感性,伸展细胞、神经细胞和垂体细胞的酯酶比肾上腺皮质和腮腺的酯酶反应更敏感。在溶液介质方面观察到的差异较小;在所应用的元素周期表不同族的金属盐中,在神经细胞中发现了最强的阻断作用。伸展细胞和立即广泛反应的垂体细胞的酯酶,以及肾上腺皮质酯酶的反应基本上不太敏感,腮腺的腺细胞甚至几乎没有反应。针对个别器官上α-萘乙酸裂解酶的不同复杂性,对这种行为的论据进行了讨论并指出。

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