Merino N, Casacó A, González A
National Center of Scientific Research (CENIC), Havana, Cuba.
Allergol Immunopathol (Madr). 1993 Jul-Aug;21(4):161-4.
A retrospective histopathological, immunocytochemical and morphometric study was done on samples of pancreas of 16 asthmatic dead humans in comparison with 6 dead control subjects, by other causes not related with allergic or endocrine diseases. A ribbon-like type of islet was the only histological feature found with the exception of one case of chronic pancreatitis. A significative increase of insulin islets (p < 0.05) was observed in the asthmatics patients while no differences in calculated area, perimeter and diameter of pancreatic islets were recorded. A probable hyperplasia of beta-cells could be related to the onset of the asthmatic crisis based on the pro-inflammatory stimulation of insulin or the action of anti-asthmatic treatments in the acute attack.
对16例哮喘死亡患者的胰腺样本进行了回顾性组织病理学、免疫细胞化学和形态计量学研究，并与6例因与过敏性或内分泌疾病无关的其他原因死亡的对照受试者进行了比较。除1例慢性胰腺炎外，唯一发现的组织学特征是带状胰岛。哮喘患者中观察到胰岛素胰岛显著增加（p<0.05），而胰腺胰岛的计算面积、周长和直径未记录到差异。基于胰岛素的促炎刺激或急性发作中抗哮喘治疗的作用，β细胞可能的增生可能与哮喘发作有关。
