Nischan P, Ebeling K, Thomas D B, Hirsch U
Clinic for Oncology, Faculty of Medicine (Charité), Humboldt University, Berlin, Germany.
Am J Epidemiol. 1993 Nov 1;138(9):697-703. doi: 10.1093/oxfordjournals.aje.a116907.
From a case-control study of the relation between oral contraceptives and breast cancer carried out in East Germany during 1982-1986, the authors obtained information on oral contraceptive use through interviews of study subjects and from the records of prescribing gynecologists. The degree of agreement regarding information from these two sources was assessed for 234 breast cancer cases and 524 controls who had ever used oral contraceptives. Agreement between information obtained from medical records and that from interviews on total duration of use, number of episodes of use, and time since first and last use was reasonably good, and levels of agreement did not differ appreciably between cases and controls. Lower levels of agreement were observed for individual brand names and the duration of use of specific brands. Attempts should be made to obtain information on specific brands from medical records when investigating the effects of individual preparations.
在1982年至1986年于东德开展的一项关于口服避孕药与乳腺癌关系的病例对照研究中，作者通过对研究对象的访谈以及妇科医生的开药记录获取了口服避孕药使用情况的信息。对234例曾使用过口服避孕药的乳腺癌病例和524例对照，评估了这两种来源信息的一致程度。从病历和访谈中获取的关于总使用时长、使用次数以及首次和末次使用时间的信息之间的一致性相当不错，病例组和对照组之间的一致水平没有明显差异。对于具体品牌名称和特定品牌的使用时长，一致水平较低。在调查个别制剂的效果时，应尝试从病历中获取关于具体品牌的信息。
