Bernstein K E, Berk B C
Department of Pathology, Emory University, Atlanta, GA.
Am J Kidney Dis. 1993 Nov;22(5):745-54. doi: 10.1016/s0272-6386(12)80441-0.
Angiotensin II is very important in the regulation of blood pressure. This small peptide binds to cell surface receptors, initiating a wide diversity of physiologic responses. There are two major subtypes of angiotensin II receptors referred to as AT1 and AT2. In this article we describe the cloning and the biochemical characterization of the AT1 receptor. Antibodies against this receptor have been used to define its tissue distribution. The AT1 receptor is a member of the seven transmembrane spanning class of receptors. It initiates a complex series of signaling events, including activation of membrane phospholipases and intracellular kinases. In the human a single AT1 receptor protein mediates virtually all the effects of angiotensin II, suggesting that tissue specificity of angiotensin II must be due to organ-specific intracellular signaling.
血管紧张素II在血压调节中非常重要。这种小肽与细胞表面受体结合，引发各种各样的生理反应。血管紧张素II受体有两种主要亚型，称为AT1和AT2。在本文中，我们描述了AT1受体的克隆及生化特性。针对该受体的抗体已被用于确定其组织分布。AT1受体是七跨膜受体家族的成员。它引发一系列复杂的信号事件，包括膜磷脂酶和细胞内激酶的激活。在人类中，单一的AT1受体蛋白几乎介导了血管紧张素II的所有效应，这表明血管紧张素II的组织特异性必定归因于器官特异性的细胞内信号传导。
