Blakemore K, Filkins K, Luthy D A, Platt L D, Medearis A L, Carlson D, Priest J, Korotkin J, Verp M S, Padilla L M
Johns Hopkins University, Baltimore, Maryland.
Am J Obstet Gynecol. 1993 Oct;169(4):1022-6. doi: 10.1016/0002-9378(93)90047-m.
The null hypothesis was that offspring of women undergoing first-trimester chorionic villus sampling do not experience a rate of birth defects exceeding background rates.
Follow-up information regarding major malformations was prospectively sought on offspring of 4105 women undergoing first-trimester chorionic villus sampling from nine centers participating in a collaborative study with the Cook obstetrics and gynecology catheter. These data were compared with data from the Collaborative Perinatal Project and other registries.
A total of 84 offspring with major malformations was identified (2.36%). Compared with background rates, there was no increase in the incidence of total malformations or specific malformations (including limb reduction defects) in the subjects. One institution experienced all three limb reduction defects in this series; the probability of this occurring by chance alone is < 1%.
Chorionic villus sampling was not found to result in an increase in major birth defects or in specific categories of birth defects in this series.
原假设为接受孕早期绒毛取样的女性所生后代出现出生缺陷的比率不超过背景比率。
前瞻性地收集了参与Cook妇产科导管协作研究的9个中心的4105名接受孕早期绒毛取样的女性所生后代的重大畸形随访信息。这些数据与围产期协作项目及其他登记处的数据进行了比较。
共确定84名后代有重大畸形（2.36%）。与背景比率相比，研究对象中总畸形或特定畸形（包括肢体减少缺陷）的发生率没有增加。该系列中的所有3例肢体减少缺陷均出现在一个机构；仅偶然发生这种情况的概率小于1%。
在本系列研究中，未发现绒毛取样会导致重大出生缺陷或特定类别的出生缺陷增加。
