Holmes L B
Teratology. 1993 Jul;48(1):7-13. doi: 10.1002/tera.1420480104.
A Workshop on Chorionic Villus Sampling (CVS) was convened by the National Institute of Child Health and Human Development (NICHD) and the American College of Obstetricians and Gynecologists at the National Institutes of Health on April 17, 1992, to discuss recent reports of an increased occurrence of malformations of the upper and lower limbs and oral structures among CVS-exposed infants. We summarize here the defects described in the CVS-exposed infants, the retrospective reassessments of published studies of the safety of CVS, the prevalence of limb deficiencies in infants not exposed to CVS, the status of the 7-9 week (conception or fertilization age) embryo, and the relevant human and animal experimental models of how CVS might be harmful to the embryo or fetus.
1992年4月17日，美国国立儿童健康与人类发展研究所（NICHD）和美国妇产科医师学会在美国国立卫生研究院召开了一次关于绒毛取样（CVS）的研讨会，以讨论近期报告中指出的，暴露于绒毛取样的婴儿出现上肢、下肢和口腔结构畸形发生率增加的情况。我们在此总结暴露于绒毛取样的婴儿中所描述的缺陷、已发表的绒毛取样安全性研究的回顾性重新评估、未暴露于绒毛取样的婴儿中肢体缺陷的患病率、7-9周（受孕或受精年龄）胚胎的状况，以及绒毛取样可能对胚胎或胎儿有害的相关人类和动物实验模型。
