Wax P M, Wang R Y, Hoffman R S, Mercurio M, Howland M A, Goldfrank L R
New York City Poison Control Center.
Ann Emerg Med. 1993 Dec;22(12):1807-12. doi: 10.1016/s0196-0644(05)80406-8.
To determine the availability and use of premixed activated charcoal in sorbitol preparations during multiple-dose activated charcoal therapy in the emergency department.
A prospective telephone survey of all 911 receiving hospitals within the catchment area of one poison center.
Hospital pharmacy supervisors and ED charge nurses.
Hospital pharmacy supervisors were surveyed about the available preparations of activated charcoal on their hospital's formulary, and ED charge nurses in these same hospitals were surveyed about the prevalence of sorbitol use in multiple-dose activated charcoal regimens.
Eleven hospitals (16%) stocked only activated charcoal in sorbitol preparations. Twenty-one hospitals (31%) had both activated charcoal in sorbitol preparations and activated charcoal without sorbitol preparations, and 35 hospitals (52%) had only activated charcoal without sorbitol preparations. Repeat dosing of sorbitol during multiple-dose activated charcoal therapy occurred in 33 of 67 (49%) of the EDs surveyed.
Sorbitol dosing is often repeated with activated charcoal during multiple-dose activated charcoal therapy in the ED because of the ready availability (and sometimes exclusive availability) of premixed activated charcoal in sorbitol preparations.
确定在急诊科多剂量活性炭治疗期间，预混活性炭在山梨醇制剂中的可用性及使用情况。
对一个毒物中心服务区域内的所有911家接收医院进行前瞻性电话调查。
医院药房主管和急诊科护士长。
就医院处方集上可用的活性炭制剂对医院药房主管进行调查，并就这些医院中多剂量活性炭治疗方案中山梨醇的使用情况对急诊科护士长进行调查。
11家医院（16%）仅储备了山梨醇制剂中的活性炭。21家医院（31%）既有山梨醇制剂中的活性炭，也有不含山梨醇的活性炭制剂，35家医院（52%）仅储备了不含山梨醇的活性炭制剂。在接受调查的67家急诊科中，有33家（49%）在多剂量活性炭治疗期间重复使用了山梨醇。
在急诊科多剂量活性炭治疗期间，由于预混山梨醇制剂中的活性炭易于获取（有时是唯一可用的），山梨醇常与活性炭一起重复给药。
