Pailleur C L, Lafont H, Guillemot R, Fleury G, Heulin A, Di Matteo J
Arch Mal Coeur Vaiss. 1976 Aug;69(8):819-24.
A cine-angiographic study was carried out in eleven patients with major aortic incompetence, in two of whom there was an associated aortic stenosis. The ventricular end-diastolic volume is always greatly increased, disproportionately to the modest increase in end-diastolic pressure. The pressure-volume relationship during filling is therefore altered, and makes it possible for a normal end-diastolic compliance (dV/dP) TD to be preserved. The indices of contractility are markedly altered, despite the recent appearance of signs of poor tolerance. These findings argue in favour of a full haemodynamic investigation and of early corrective surgery.
对11例重度主动脉瓣关闭不全患者进行了电影血管造影研究，其中2例合并主动脉瓣狭窄。心室舒张末期容积总是显著增加，与舒张末期压力的适度增加不成比例。因此，充盈期的压力-容积关系发生改变，使得正常的舒张末期顺应性（dV/dP）TD得以保留。尽管近期出现耐受性差的体征，但收缩性指标仍有显著改变。这些发现支持进行全面的血流动力学检查和早期矫正手术。
