Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3-Kasumi, Minami-ku, Hiroshima City, Hiroshima, 734-8551, Japan.
Breast Cancer Res Treat. 2021 May;187(1):125-133. doi: 10.1007/s10549-020-06088-1. Epub 2021 Jan 23.
This study compares the sensitivity of dedicated breast positron emission tomography (DbPET) and whole body positron emission tomography (WBPET) in detecting invasive breast cancer based on tumor size and biology. Further, we explored the relationship between maximum standardized uptake value (SUVmax) of DbPET and biological features of the tumor.
A total of 639 invasive breast cancer lesions subjected to both DbPET and WBPET before surgery, between January 2016 and May 2019, were included in the study. The sensitivity of DbPET and WBPET in detection and the biology of the tumor according to the clinicopathological features were retrospectively evaluated.
The overall sensitivity of DbPET was higher than that of WBPET (91.4% vs. 80.3%, p < 0.001). Subcentimetric tumors were significant (80.9% vs. 54.3%, p < 0.001). Regardless of the nuclear grade, DbPET could detect more lesions than WBPET. The SUVmax was positively correlated with tumor size (R = 0.395, p < 0.001) and the nuclear grade (p < 0.001). Luminal A-like breast cancer had significantly lower SUVmax values than the other subtypes (p < 0.001).
DbPET is superior to WBPET in the detection of subcentimetric, low-grade breast cancers. Further, by using SUVmax, DbPET can distinguish luminal A-like breast cancer from the other subtypes.
本研究旨在比较专用乳腺正电子发射断层扫描（DbPET）和全身正电子发射断层扫描（WBPET）在基于肿瘤大小和生物学特征检测浸润性乳腺癌方面的敏感性。此外，我们还探讨了 DbPET 最大标准化摄取值（SUVmax）与肿瘤生物学特征之间的关系。
回顾性分析了 2016 年 1 月至 2019 年 5 月期间 639 例接受 DbPET 和 WBPET 检查的术前浸润性乳腺癌患者的资料。评估 DbPET 和 WBPET 在检测中的敏感性以及根据临床病理特征的肿瘤生物学特征。
DbPET 的总体敏感性高于 WBPET（91.4% vs. 80.3%，p<0.001）。亚厘米大小的肿瘤具有显著差异（80.9% vs. 54.3%，p<0.001）。无论核级如何，DbPET 都能比 WBPET 检测到更多的病变。SUVmax 与肿瘤大小呈正相关（R=0.395，p<0.001），与核级也呈正相关（p<0.001）。Luminal A 样乳腺癌的 SUVmax 值明显低于其他亚型（p<0.001）。
DbPET 在检测亚厘米、低级别乳腺癌方面优于 WBPET。此外，通过使用 SUVmax，DbPET 可以将 Luminal A 样乳腺癌与其他亚型区分开来。
