人类血液循环中的β-淀粉样蛋白前体A4。

The beta A4 amyloid protein precursor in human circulation.

作者信息

Bush A I, Beyreuther K, Masters C L

机构信息

Department of Pathology, University of Melbourne, Victoria Australia.

出版信息

Ann N Y Acad Sci. 1993 Sep 24;695:175-82. doi: 10.1111/j.1749-6632.1993.tb23048.x.

DOI:10.1111/j.1749-6632.1993.tb23048.x

PMID:8239279

Abstract

beta A4, the principal constituent of the brain amyloid collections in Alzheimer's disease, is derived from a much larger precursor, the amyloid protein precursor (APP). APP exists in the blood as full-length, potentially amyloidogenic forms in platelets, and as an attenuated species in plasma and T-lymphocytes. Studies of circulating APP facilitate the elaboration of the function of this protein, as well as the elucidation of its processing in health and disease.

摘要

β-淀粉样蛋白4（beta A4）是阿尔茨海默病脑淀粉样蛋白沉积物的主要成分，它来源于一种大得多的前体——淀粉样前体蛋白（APP）。APP在血液中以血小板中全长的、潜在的淀粉样生成形式存在，在血浆和T淋巴细胞中则以一种截短形式存在。对循环APP的研究有助于阐明这种蛋白质的功能，以及其在健康和疾病状态下的加工过程。