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Platelet-generated amyloid beta peptides in Alzheimer's disease and glaucoma.阿尔茨海默病和青光眼患者血小板生成的淀粉样β肽。
Histol Histopathol. 2019 Aug;34(8):843-856. doi: 10.14670/HH-18-111. Epub 2019 Apr 4.
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The cAMP/PKA Pathway Inhibits Beta-amyloid Peptide Release from Human Platelets.cAMP/PKA 通路抑制人血小板中β-淀粉样肽的释放。
Neuroscience. 2019 Jan 15;397:159-171. doi: 10.1016/j.neuroscience.2018.11.025. Epub 2018 Nov 26.
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β-Amyloid promotes platelet activation and activated platelets act as bridge between risk factors and Alzheimer's disease.β-淀粉样蛋白促进血小板活化，而活化的血小板则充当了风险因素与阿尔茨海默病之间的桥梁。
Mech Ageing Dev. 2022 Oct;207:111725. doi: 10.1016/j.mad.2022.111725. Epub 2022 Aug 19.
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A Peptide Originated from Platelets Promises New Strategy in Anti-Alzheimer's Drug Development.血小板来源的肽有望成为抗阿尔茨海默病药物研发的新策略。
Biomed Res Int. 2017;2017:3948360. doi: 10.1155/2017/3948360. Epub 2017 Sep 5.
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Alternative platelet activation pathways and their role in neurodegenerative diseases.替代的血小板激活途径及其在神经退行性疾病中的作用。
Neurobiol Dis. 2021 Nov;159:105512. doi: 10.1016/j.nbd.2021.105512. Epub 2021 Sep 16.
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Amyloid β-peptide-dependent activation of human platelets: essential role for Ca2+ and ADP in aggregation and thrombus formation.淀粉样β肽依赖性激活人血小板：Ca2+和ADP在聚集和血栓形成中的重要作用。
Biochem J. 2014 Sep 15;462(3):513-23. doi: 10.1042/BJ20140307.
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Processing of amyloid precursor protein as a biochemical link between atherosclerosis and Alzheimer's disease.淀粉样前体蛋白的加工过程作为动脉粥样硬化与阿尔茨海默病之间的生化联系。
Cardiovasc Hematol Disord Drug Targets. 2006 Mar;6(1):21-34. doi: 10.2174/187152906776092695.
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Release of beta-amyloid from high-density platelets: implications for Alzheimer's disease pathology.β-淀粉样蛋白从高密度血小板中的释放：对阿尔茨海默病病理学的影响。
Ann N Y Acad Sci. 2007 Jan;1096:170-8. doi: 10.1196/annals.1397.082.
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β-sitosterol inhibits high cholesterol-induced platelet β-amyloid release.β-谷甾醇抑制高胆固醇诱导的血小板β-淀粉样蛋白释放。
J Bioenerg Biomembr. 2011 Dec;43(6):691-7. doi: 10.1007/s10863-011-9383-2. Epub 2011 Oct 4.
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Amyloid precursor protein is required for in vitro platelet adhesion to amyloid peptides and potentiation of thrombus formation.淀粉样前体蛋白是体外血小板黏附于淀粉样肽和增强血栓形成所必需的。
Cell Signal. 2018 Dec;52:95-102. doi: 10.1016/j.cellsig.2018.08.017. Epub 2018 Aug 30.
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HSV-1 Infection in Retinal Pigment Epithelial Cells: A Possible Contribution to Age-Related Macular Degeneration.单纯疱疹病毒1型在视网膜色素上皮细胞中的感染：对年龄相关性黄斑变性的可能作用。
Viruses. 2025 Jul 29;17(8):1056. doi: 10.3390/v17081056.
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The Role of Extracellular Vesicles and Microparticles in Central Nervous System Disorders: Mechanisms, Biomarkers, and Therapeutic Potential.细胞外囊泡和微粒在中枢神经系统疾病中的作用：机制、生物标志物及治疗潜力
Cell Mol Neurobiol. 2024 Dec 3;44(1):82. doi: 10.1007/s10571-024-01518-w.
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Pathology of Amyloid-β (Aβ) Peptide Peripheral Clearance in Alzheimer's Disease.阿尔茨海默病中淀粉样β（Aβ）肽外周清除的病理学。
Int J Mol Sci. 2024 Oct 11;25(20):10964. doi: 10.3390/ijms252010964.
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Elevated C-Reactive Protein in Older Men With Chronic Pain: Association With Plasma Amyloid Levels and Hippocampal Volume.老年男性慢性疼痛患者 C 反应蛋白升高：与血浆淀粉样蛋白水平和海马体积的关系。
J Gerontol A Biol Sci Med Sci. 2024 Nov 1;79(11). doi: 10.1093/gerona/glae206.
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Correlation analysis of peripheral platelet markers and disease phenotypes in Alzheimer's disease.阿尔茨海默病外周血小板标志物与疾病表型的相关性分析。
Alzheimers Dement. 2024 Jun;20(6):4366-4372. doi: 10.1002/alz.13841. Epub 2024 May 7.
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The association between methylmalonic acid, a biomarker of mitochondrial dysfunction, and cause-specific mortality in Alzheimer's disease and Parkinson's disease.线粒体功能障碍生物标志物甲基丙二酸与阿尔茨海默病和帕金森病的特定病因死亡率之间的关联。
Heliyon. 2024 Apr 15;10(8):e29357. doi: 10.1016/j.heliyon.2024.e29357. eCollection 2024 Apr 30.
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Potential Retinal Biomarkers in Alzheimer's Disease.阿尔茨海默病的潜在视网膜生物标志物。
Int J Mol Sci. 2023 Oct 31;24(21):15834. doi: 10.3390/ijms242115834.
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Immune-mediated platelet depletion augments Alzheimer's disease neuropathological hallmarks in APP-PS1 mice.免疫介导的血小板耗竭增强 APP-PS1 小鼠的阿尔茨海默病神经病理特征。
Aging (Albany NY). 2023 Feb 1;15(3):630-649. doi: 10.18632/aging.204502.
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Gamma-Synuclein Dysfunction Causes Autoantibody Formation in Glaucoma Patients and Dysregulation of Intraocular Pressure in Mice.γ-突触核蛋白功能障碍导致青光眼患者自身抗体形成及小鼠眼压调节异常。
Biomedicines. 2022 Dec 27;11(1):60. doi: 10.3390/biomedicines11010060.
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Glaucoma and Alzheimer: Neurodegenerative disorders show an adrenergic dysbalance.青光眼和阿尔茨海默病：神经退行性疾病表现出肾上腺素能失衡。
PLoS One. 2022 Oct 6;17(10):e0272811. doi: 10.1371/journal.pone.0272811. eCollection 2022.
本文引用的文献
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in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors.在阿尔茨海默病患者大脑中：用小分子抑制剂治疗疾病的因果证据。
Sci Adv. 2019 Jan 23;5(1):eaau3333. doi: 10.1126/sciadv.aau3333. eCollection 2019 Jan.
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Retinoid x receptor modulation protects against ER stress response and rescues glaucoma phenotypes in adult mice.视黄醇 X 受体调节可预防内质网应激反应并挽救成年小鼠的青光眼表型。
Exp Neurol. 2019 Apr;314:111-125. doi: 10.1016/j.expneurol.2019.01.015. Epub 2019 Jan 28.
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The Platelet Napoleon Complex-Small Cells, but Big Immune Regulatory Functions.血小板拿破仑情结——小细胞，大免疫调节功能。
Annu Rev Immunol. 2019 Apr 26;37:125-144. doi: 10.1146/annurev-immunol-042718-041607. Epub 2018 Nov 28.
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Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer's Disease.血脑屏障破坏和多种微生物脑侵袭作为阿尔茨海默病决定因素的遗传学、转录组学、蛋白质组学及流行病学证据
J Alzheimers Dis Rep. 2017 Sep 28;1(1):125-157. doi: 10.3233/ADR-170017.
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Endogenous amyloid-β mediates memory forgetting in the normal brain.内源性淀粉样蛋白-β介导正常大脑中的记忆遗忘。
Biochem Biophys Res Commun. 2018 Nov 30;506(3):492-497. doi: 10.1016/j.bbrc.2018.10.118. Epub 2018 Oct 23.
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Factor XII Activation Promotes Platelet Consumption in the Presence of Bacterial-Type Long-Chain Polyphosphate In Vitro and In Vivo.因子 XII 的激活促进了体外和体内细菌型长链多聚磷酸盐存在时血小板的消耗。
Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1748-1760. doi: 10.1161/ATVBAHA.118.311193.
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Platelets isolated from an Alzheimer mouse damage healthy cortical vessels and cause inflammation in an organotypic ex vivo brain slice model.从阿尔茨海默病小鼠中分离出的血小板会损伤健康的皮质血管，并在器官型脑片体外模型中引起炎症。
Sci Rep. 2018 Oct 19;8(1):15483. doi: 10.1038/s41598-018-33768-2.
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Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice.慢性口服牙周病病原体可导致野生型小鼠脑内炎症、神经退行性变和淀粉样β生成。
PLoS One. 2018 Oct 3;13(10):e0204941. doi: 10.1371/journal.pone.0204941. eCollection 2018.
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Associations between recent and established ophthalmic conditions and risk of Alzheimer's disease.近期和已确诊的眼科疾病与阿尔茨海默病风险之间的关联。
Alzheimers Dement. 2019 Jan;15(1):34-41. doi: 10.1016/j.jalz.2018.06.2856. Epub 2018 Aug 8.
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Human blood platelets and viruses: defense mechanism and role in the removal of viral pathogens.人类血小板与病毒：防御机制及在清除病毒病原体中的作用
Thromb J. 2018 Jul 17;16:16. doi: 10.1186/s12959-018-0170-8. eCollection 2018.
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