Uno H, Walker L C
Regional Primate Research Center, School of Medicine, University of Wisconsin, Madison 53706.
Ann N Y Acad Sci. 1993 Sep 24;695:232-5. doi: 10.1111/j.1749-6632.1993.tb23058.x.
Autopsy surveillance of 186 rhesus monkeys aged 20 to 36 years revealed that development of major geriatric diseases such as emphysema, coronary sclerosis, and cancer increased rapidly after the age of 25 years, and nearly 70% of the monkeys in each cohort group died by 30 years. According to our 12-year longitudinal survey, the age of biosenescence in captive rhesus monkeys begins around 25 years and the maximum longevity is 36 years. The incidence of cerebral beta-amyloidosis associated with plaque formation and cerebral angiopathy was observed in 51 brains of rhesus monkeys aged 25 to 36 years. Lesions were found in 31 of 51 aged brains (60%) and 6 monkeys over 34 years of age were all severely affected. Despite the size of the plaque, nearly all of them showed immunopositive beta-amyloid. Cerebral angiopathy coexisted in 10 of 31 plaque-positive brains. The basal prefrontal gyrus was the most common site and contained the highest density of plaques, followed by the amygdala region. The amyloid in the liver, spleen, adrenal and pancreatic islets in visceral amyloidosis showed no positivity to the beta-amyloid demonstrated in the brain. As in aged human brains, the incidence of age-dependent cerebral beta-amyloidosis in captive rhesus monkeys showed great individual variation.
对186只年龄在20至36岁之间的恒河猴进行尸检监测发现，诸如肺气肿、冠状动脉硬化和癌症等主要老年疾病的发生率在25岁之后迅速上升，每个队列组中近70%的猴子在30岁时死亡。根据我们为期12年的纵向调查，圈养恒河猴的生物衰老年龄始于25岁左右，最长寿命为36岁。在25至36岁的恒河猴的51个大脑中观察到与斑块形成和脑血管病变相关的脑β-淀粉样变性的发生率。在51个老年大脑中有31个（60%）发现有病变，6只34岁以上的猴子均受到严重影响。尽管斑块大小不一，但几乎所有斑块都显示β-淀粉样蛋白免疫阳性。31个斑块阳性大脑中有10个同时存在脑血管病变。基底前额叶回是最常见的部位，斑块密度最高，其次是杏仁核区域。内脏淀粉样变性中肝脏、脾脏、肾上腺和胰岛中的淀粉样蛋白对大脑中显示的β-淀粉样蛋白无阳性反应。与老年人类大脑一样，圈养恒河猴中年龄依赖性脑β-淀粉样变性的发生率存在很大的个体差异。
