Thomas Jeremy L, Nilaver Benjamin I, Lomniczi Alejandro, Brown Donald I, Appleman Maria-Luisa, Kohama Steven G, Urbanski Henryk F
Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, USA.
Department of Physiology & Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada.
J Alzheimers Dis Rep. 2024 Jan 9;8(1):25-32. doi: 10.3233/ADR-230184. eCollection 2024.
Rhesus macaques develop amyloid-β (Aβ) plaques during old age, but it is unclear how extensively they express other pathological hallmarks of dementia. Here we used immunohistochemistry to examine expression of phosphorylated tau (pTau) protein and cytoplasmic inclusions of TAR DNA binding protein 43 kDa (TDP-43) within the amygdala of young and old males, and also in old surgically-menopausal females that were maintained on regular or obesogenic diets. Only one animal, a 23-year-old female, showed pTau expression and none showed TDP-43 inclusions. What genetic and/or environmental factors protect macaques from expressing more severe human neuro-pathologies remains an interesting unresolved question.
恒河猴在老年时会形成β-淀粉样蛋白（Aβ）斑块，但目前尚不清楚它们在多大程度上表达痴呆症的其他病理特征。在这里，我们使用免疫组织化学方法来检测年轻和老年雄性恒河猴杏仁核中磷酸化tau（pTau）蛋白的表达以及43 kDa的TAR DNA结合蛋白（TDP-43）的细胞质包涵体，同时也检测了接受常规饮食或致肥胖饮食的老年手术绝经雌性恒河猴的情况。只有一只23岁的雌性动物显示出pTau表达，没有一只显示出TDP-43包涵体。哪些遗传和/或环境因素保护恒河猴不表达更严重的人类神经病理学特征仍然是一个有趣的未解决问题。
