Maerens-Tchokokam B, Bailly N, Collet E, Dalac S, Rat P, Lambert D
Service de Dermatologie, Hôpital du Bocage, Dijon.
Ann Dermatol Venereol. 1993;120(3):215-7.
The authors present 3 cases of melanoma associated with a parathyroid adenoma discovered by routine measurement of blood calcium levels. The melanomas were differently located and had different histological degrees. Hypercalcaemia is an infrequent complication of melanoma. According to data found in the literature, it is most often consecutive to bone metastases. The other causes of hypercalcaemia are metastatic extension of melanoma to the parathyroid glands, secretion of parathormone-related peptide (PTH-RP) and the actions of prostaglandins, vitamin D and the osteoclast-activating factor (OAF). Primary hyperparathyroidism due to adenoma has seldom been described associated with melanoma.
作者报告了3例通过常规血钙水平检测发现的与甲状旁腺腺瘤相关的黑色素瘤病例。这些黑色素瘤的位置不同，组织学分级也不同。高钙血症是黑色素瘤罕见的并发症。根据文献资料，它最常见于骨转移之后。高钙血症的其他原因包括黑色素瘤转移至甲状旁腺、甲状旁腺激素相关肽（PTH-RP）的分泌以及前列腺素、维生素D和破骨细胞激活因子（OAF）的作用。很少有因腺瘤导致的原发性甲状旁腺功能亢进与黑色素瘤相关的描述。
