Van Landuyt H, Mougin C, Drobacheff C, Bernard C, Merle C, Lab M, Laurent R
Ann Dermatol Venereol. 1993;120(4):281-6.
Anal and genital lesions caused by human papilloma virus (HPV) may be associated with severe dysplasia and cancer, chiefly in cases of "high risk" HPV types 16, 18, 31, 35, 51. The frequency of HPV infections and the severity of genital cancers seem to be increased in patients with human immunodeficiency virus (HIV) infection. PATIENTS AND METHOD. The distribution of different HPV types was compared with the anatomical and clinical features of the lesions in two populations, one HIV+ (n = 40) and the other HIV- (n = 48), who had anal and genital lesions. The HPV DNA was determined by molecular hybridization in situ, using biotinylated probes which recognized HPV types 6/11, 16/8 and 31/35/51 on 99 lesions. RESULTS. HIV+ subjects differed from HIV- subjects in that a higher proportion of them had anal lesions (50 p. 100 vs 10 p. 100) and condyloma latum (80 p. 100 vs 50 p. 100). Koilocytosis without dysplasia was more often found in HIV- subjects (12.5 p. 100 vs 55 p. 100). Conversely, dysplasia was more frequent among the lesions of HIV+ subjects: grade I 39.5 p. 100 vs 17.5 p. 100; grade II 25 p. 100 vs 4 p. 100; grade III 12.5 p. 100 vs 0 p. 100. Koilocytosis was preferentially associated with condyloma acuminatum. In HIV+ subjects the DNA of HPV, detected in 73 p. 100 of the lesions, was "high risk" HPV DNA in 86 p. 100 of the cases, whereas in HIV- subjects 51 p. 100 of the samples were positive in hybridization, and 61.5 p. 100 had "low risk" HPV DNA. In subjects of all groups "high risk" HPV was found in dysplastic lesions. CONCLUSION. HIV seropositive subjects show an imbalanced distribution of HPV with predominance of "high risk" HPV. This suggests that immunodepression encourages infection by this oncogenic virus, thereby contributing to the frequency of cancer in HIV+ subjects.
人乳头瘤病毒（HPV）引起的肛门和生殖器病变可能与严重发育异常及癌症相关，主要见于16、18、31、35、51型等“高危”HPV感染病例。人类免疫缺陷病毒（HIV）感染患者中HPV感染频率及生殖器癌症严重程度似乎有所增加。患者与方法。比较了两组患有肛门和生殖器病变人群中不同HPV类型的分布情况与病变的解剖学及临床特征，一组为HIV阳性（n = 40），另一组为HIV阴性（n = 48）。采用生物素化探针通过原位分子杂交法对99处病变检测HPV DNA，这些探针可识别6/11、16/18和31/35/51型HPV。结果。HIV阳性受试者与HIV阴性受试者不同，前者肛门病变比例更高（50%对10%），扁平湿疣比例更高（80%对50%）。无发育异常的挖空细胞在HIV阴性受试者中更常见（12.5%对55%）。相反，发育异常在HIV阳性受试者的病变中更频繁：I级为39.5%对17.5%；II级为25%对4%；III级为12.5%对0%。挖空细胞优先与尖锐湿疣相关。在HIV阳性受试者中，73%的病变检测到HPV DNA，其中86%的病例为“高危”HPV DNA，而在HIV阴性受试者中，51%的样本杂交呈阳性，61.5%有“低危”HPV DNA。在所有组的受试者中，发育异常病变中均发现“高危”HPV。结论。HIV血清阳性受试者HPV分布不均衡，“高危”HPV占主导。这表明免疫抑制促使这种致癌病毒感染，从而导致HIV阳性受试者中癌症发生率增加。
