Bryan J T, Stoler M H, Tyring S K, McClowry T, Fife K H, Brown D R
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202-5124, USA.
J Med Virol. 1998 Jan;54(1):69-73.
Cancer-associated human papillomavirus (HPV) types are detected in genital warts removed from immunosuppressed individuals more commonly than from those occurring in otherwise healthy individuals. The prognosis of genital warts containing cancer-associated HPV types is not known. Because it is assumed that genital warts are benign lesions, they are usually treated by destructive therapies without prior knowledge of histopathology. The aim of the present study was to determine whether genital warts from individuals with or without human immunodeficiency virus (HIV) contain high-risk HPV types or areas of dysplasia. The study design was a nonrandomized analysis of genital warts removed by excision biopsy from 15 HIV-infected patients and 15 HIV-negative patients. The tissue was analyzed for HPV DNA by hybrid capture, and microscopic sections of each biopsy were examined for areas of dysplasia. Genital warts from HIV-infected patients contained cancer-associated ("high risk") HPV types in 9 of 15 cases, including 1 that contained only a high-risk type. High-grade dysplastic abnormalities were present in 2 of the 15 lesions from this group, both of which contained high-risk HPV types. Four genital warts removed from HIV-negative patients contained high-risk HPV types, but none contained dysplastic abnormalities. It is concluded that genital warts from HIV-infected patients often contain high-risk HPV types. Such lesions may exhibit dysplastic changes. The frequency of dysplastic changes in genital warts from HIV-infected patients is not known. Biopsy of genital warts may be indicated prior to additional therapy in HIV-infected patients, and surgical removal should be considered as a preferred treatment option in these patients.
在免疫抑制个体切除的生殖器疣中检测到癌症相关的人乳头瘤病毒（HPV）类型，比在其他方面健康个体中出现的生殖器疣更为常见。含有癌症相关HPV类型的生殖器疣的预后尚不清楚。由于假定生殖器疣是良性病变，它们通常在没有组织病理学先验知识的情况下通过破坏性疗法进行治疗。本研究的目的是确定感染或未感染人类免疫缺陷病毒（HIV）个体的生殖器疣是否含有高危HPV类型或发育异常区域。研究设计是对15例HIV感染患者和15例HIV阴性患者通过切除活检切除的生殖器疣进行非随机分析。通过杂交捕获分析组织中的HPV DNA，并检查每个活检的显微切片是否存在发育异常区域。15例HIV感染患者的生殖器疣中有9例含有癌症相关（“高危”）HPV类型，其中1例仅含有高危类型。该组15个病变中有2个存在高级别发育异常异常，两者均含有高危HPV类型。从HIV阴性患者切除的4个生殖器疣含有高危HPV类型，但均未含有发育异常异常。结论是，HIV感染患者的生殖器疣通常含有高危HPV类型。此类病变可能表现出发育异常变化。HIV感染患者生殖器疣中发育异常变化的频率尚不清楚。在对HIV感染患者进行额外治疗之前，可能需要对生殖器疣进行活检，并应考虑将手术切除作为这些患者的首选治疗选择。
