昼夜节律阶段依赖性给药方案对异帕米星在大鼠体内肾毒性和药代动力学的影响。

Influence of circadian-stage-dependent dosing schedule on nephrotoxicity and pharmacokinetics of isepamicin in rats.

作者信息

Yoshiyama Y, Nishikawa S, Sugiyama T, Kobayashi T, Shimada H, Tomonaga F, Ohdo S, Ogawa N, Nakano S

机构信息

School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.

出版信息

Antimicrob Agents Chemother. 1993 Sep;37(9):2042-3. doi: 10.1128/AAC.37.9.2042.

DOI:10.1128/AAC.37.9.2042

PMID:8239630

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC188120/

Abstract

Nephrotoxicity was more marked in rats receiving isepamicin at midlight than at middark. And, the once-daily administration at middark induced a lesser degree of nephrotoxicity than the twice-daily injection, which indicates that the once-daily treatment therapy may have potential value in the clinical use of aminoglycosides.

摘要

接受异帕米星治疗的大鼠在光照中期比黑暗中期的肾毒性更明显。而且，在黑暗中期每日给药一次所诱导的肾毒性程度低于每日注射两次，这表明每日一次的治疗方案在氨基糖苷类药物的临床应用中可能具有潜在价值。