Luo M, Takagi H, Tsubone M, Ando C, Ogata K, Shrestha P, Mori M
Department of Oral and Maxillofacial Surgery, Asahi University School of Dentistry, GIFU, Japan.
Arch Anat Cytol Pathol. 1993;41(2):68-74.
The distribution of fibronectin in the normal and pleomorphic adenoma of the salivary gland was investigated in forty cases of surgically resected tumor specimens. The immunoreactivity of fibronectin using polyclonal antibody (anti-fibronectin A2 45, Dakopatts, Denmark) was detected in the cytoplasm of intercalated duct cells and certain striated duct cells in normal salivary glands. Pleomorphic adenoma showed few fibronectin positive cells with a scattered or isolated distribution within the epithelial tumor elements of tubulo-ductal or solid foci of tumor cells. Modified myoepithelial cells and luminal cells of tubulo-ductal structures reacted strongly to fibronectin. In hyalinous, myxoid and chondroid areas, fibrillary myoepithelial cells expressed strongly positive reactivity but with diffuse staining in the myxoid and chondroid areas suggesting that fibronectin plays an important role in tumor cell-extracellular matrix interactions to produce the complex histopathological features of pleomorphic adenoma.
在40例手术切除的肿瘤标本中，研究了纤连蛋白在正常涎腺及涎腺多形性腺瘤中的分布情况。使用多克隆抗体（抗纤连蛋白A2 45，丹麦达科帕茨公司）检测到正常涎腺闰管细胞和某些纹管细胞的细胞质中有纤连蛋白的免疫反应性。多形性腺瘤显示纤连蛋白阳性细胞很少，在肿瘤细胞的管-导管或实性灶的上皮肿瘤成分中呈散在或孤立分布。管-导管结构的改良肌上皮细胞和管腔细胞对纤连蛋白反应强烈。在透明样、黏液样和软骨样区域，纤维状肌上皮细胞表达强烈的阳性反应，但在黏液样和软骨样区域呈弥漫性染色，提示纤连蛋白在肿瘤细胞-细胞外基质相互作用中起重要作用，从而产生多形性腺瘤复杂的组织病理学特征。
