猪蛔虫体内驱虫药与组胺之间的相互作用
The interaction between anthelmintic drugs and histamine in Ascaris suum.
作者信息
Phillips J L, Sturman G, West G B
出版信息
Br J Pharmacol. 1976 Jul;57(3):417-20. doi: 10.1111/j.1476-5381.1976.tb07683.x.
Abstract
1 Piperazine reduced the histamine content of Ascaris suum, yet it greatly increased the uptake of histamine from the surrounding medium, the neuromuscular structures of the nematode preferentially increasing in amount. 2 Bephenium reduced the histamine content of Ascaris and the uptake of histamine from the surrounding medium. However, the relative amount in the neuromuscular structures increased. 3 The flaccid paralysing action of piperazine may thus involve increased histamine absorption whereas the spastic paralysing action of bephenium may be independent of histamine.
摘要
- 哌嗪降低了猪蛔虫的组胺含量，但它极大地增加了从周围介质中摄取组胺的量，线虫的神经肌肉结构的量优先增加。2. 苄酚宁降低了蛔虫的组胺含量以及从周围介质中摄取组胺的量。然而，神经肌肉结构中的相对量增加了。3. 因此，哌嗪的弛缓性麻痹作用可能涉及组胺吸收的增加，而苄酚宁的痉挛性麻痹作用可能与组胺无关。
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本文引用的文献
1
A method for the fluorometric assay of histamine in tissues.一种用于组织中组胺荧光测定的方法。
J Pharmacol Exp Ther. 1959 Nov;127:182-6.
2
The formation of histamine in the rat.大鼠体内组胺的形成。
J Pharm Pharmacol. 1961 Feb;13:75-82. doi: 10.1111/j.2042-7158.1961.tb11791.x.
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Studies on the role of histamine and 5-hydroxytryptamine in immunity against the nematode Trichostrongylus colubriformis. I. In vivo and in vitro effects of the amines.组胺和5-羟色胺在抗蛇形毛圆线虫免疫中作用的研究。I. 胺类的体内和体外效应
Int Arch Allergy Appl Immunol. 1974;46(1):1-13. doi: 10.1159/000231108.
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Chemical transmission in invertebrate central nervous systems and neuromuscular junctions.无脊椎动物中枢神经系统和神经肌肉接头中的化学传递。
Physiol Rev. 1973 Jan;53(1):1-119. doi: 10.1152/physrev.1973.53.1.1.
5
Studies on the role of histamine and 5-hydroxytryptamine in immunity against the nematode Trichostrongylus colubriformis. II. Amine levels in the intestine of infected guinea-pigs.组胺和5-羟色胺在抗蛇形毛圆线虫免疫中的作用研究。II. 感染豚鼠肠道中的胺水平。
Int Arch Allergy Appl Immunol. 1974;46(1):14-27. doi: 10.1159/000231109.
6
Proceedings: A possible mode of action of piperazine.论文集：哌嗪的一种可能作用方式。
Br J Pharmacol. 1975 Jun;54(2):219P-220P. doi: 10.1111/j.1476-5381.1975.tb06932.x.
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