四咪唑对蛔虫体肌的麻痹作用机制。
The mechanism of the paralysing action of tetramisole on Ascaris somatic muscle.
作者信息
Aceves J, Erlij D, Martínez-Marañón R
出版信息
Br J Pharmacol. 1970 May;38(3):602-7. doi: 10.1111/j.1476-5381.1970.tb10601.x.
Abstract
- Tetramisole (100 mug/ml) paralysed live Ascaris in 3 min.2. Tetramisole (10 mug/ml) caused a sustained contraction of the isolated somatic muscles of the worm. This contraction was not blocked by curare nor by piperazine.3. Tetramisole reduced the resting potential of Ascaris muscle from 34+/-4 to 10+/-1 mV.4. Tetramisole caused contraction of Ascaris muscle previously depolarized with high K(+) solutions. This observation suggests that tetramisole can induce a contracture that is independent of membrane depolarization.
摘要
四咪唑（100微克/毫升）在3分钟内使活蛔虫麻痹。
四咪唑（10微克/毫升）引起蛔虫离体体壁肌肉的持续收缩。这种收缩不受箭毒或哌嗪的阻断。
四咪唑使蛔虫肌肉的静息电位从34±4毫伏降至10±1毫伏。
四咪唑使先前用高钾溶液去极化的蛔虫肌肉发生收缩。这一观察结果表明，四咪唑可诱导一种与膜去极化无关的挛缩。
相似文献
1
The mechanism of the paralysing action of tetramisole on Ascaris somatic muscle.四咪唑对蛔虫体肌的麻痹作用机制。
Br J Pharmacol. 1970 May;38(3):602-7. doi: 10.1111/j.1476-5381.1970.tb10601.x.
2
Fundamental studies of anthelmintics (XXII). Electrophysiological studies of 1-(2-(dodecyloxy) ethyl)pyrrolidine hydrochloriide (DEP) on Ascaris muscle cells.驱虫药的基础研究（XXII）。1-（2-（十二烷氧基）乙基）吡咯烷盐酸盐（DEP）对蛔虫肌肉细胞的电生理研究。
Jpn J Pharmacol. 1974 Apr;24(2):291-8. doi: 10.1254/jjp.24.291.
3
Electrophysiological effects of piperazine and diethylcarbamazine on Ascaris suum somatic muscle.哌嗪和乙胺嗪对猪蛔虫体肌的电生理效应。
Br J Pharmacol. 1982 Oct;77(2):255-65. doi: 10.1111/j.1476-5381.1982.tb09294.x.
4
The effects of avermectin and drugs related to acetylcholine and 4-aminobutyric acid on neurotransmission in Ascaris suum.阿维菌素以及与乙酰胆碱和4-氨基丁酸相关的药物对猪蛔虫神经传递的影响。
Mol Biochem Parasitol. 1984 Oct;13(2):213-25. doi: 10.1016/0166-6851(84)90114-2.
5
Aspects of the pharmacology of a new anthelmintic: pyrantel.一种新型驱虫药：噻嘧啶的药理学方面。
Br J Pharmacol. 1970 Feb;38(2):332-44. doi: 10.1111/j.1476-5381.1970.tb08521.x.
6
MECHANISM OF THE PARALYSING ACTION OF PIPERAZINE ON ASCARIS MUSCLE.哌嗪对蛔虫肌肉的麻痹作用机制
Br J Pharmacol Chemother. 1964 Jun;22(3):463-77. doi: 10.1111/j.1476-5381.1964.tb01701.x.
7
Correlation of myosin light chain phosphorylation and gamma aminobutyric acid receptors in Ascaris suum muscle.猪蛔虫肌肉中肌球蛋白轻链磷酸化与γ-氨基丁酸受体的相关性
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987;87(1):23-9. doi: 10.1016/0742-8413(87)90174-5.
8
[Experimental study of the anthelmintic tetramisole].[驱虫药四咪唑的实验研究]
Med Parazitol (Mosk). 1971 Jul-Aug;40(4):414-9.
9
10
Screen for anthelmintics, using larvae of Ascaris suum.使用猪蛔虫幼虫筛选驱虫药。
Am J Vet Res. 1986 Apr;47(4):869-73.
引用本文的文献
1
Sensory experience controls dendritic structure and behavior by distinct pathways involving degenerins.感觉体验通过涉及退化素的不同途径控制树突结构和行为。
Elife. 2025 Jan 10;14:e83973. doi: 10.7554/eLife.83973.
2
Scaffolds imparting anthelmintic activity: recent advancements and SAR studies.具有驱虫活性的支架：最新进展与构效关系研究
Mol Divers. 2025 Feb;29(1):783-816. doi: 10.1007/s11030-024-10869-x. Epub 2024 Jul 31.
3
A Landscape on Lymphatic Filariasis with its Effects and Recent Advanced Treatments.淋巴丝虫病的景观及其影响和最近的先进治疗方法。
Recent Adv Antiinfect Drug Discov. 2024;19(3):197-215. doi: 10.2174/0127724344266902231117112109.
4
Anthelmintic efficacy evaluation and mechanism of N-methylbenzo[d]oxazol-2-amine.N-甲基苯并[d]恶唑-2-胺的驱虫疗效评价及作用机制。
Sci Rep. 2023 Dec 21;13(1):22840. doi: 10.1038/s41598-023-50305-y.
5
Calcineurin-Dependent Homeostatic Response of Muscle Cells upon Prolonged Activation of Acetylcholine Receptors.钙调神经磷酸酶依赖性肌肉细胞在乙酰胆碱受体持续激活后的内稳态反应。
Cells. 2023 Sep 3;12(17):2201. doi: 10.3390/cells12172201.
6
Programmed cell death pathways as targets for developing antifilarial drugs: Lessons from the recent findings.程序性细胞死亡途径作为抗丝虫药物开发的靶点：来自最新发现的启示。
J Cell Mol Med. 2023 Oct;27(19):2819-2840. doi: 10.1111/jcmm.17913. Epub 2023 Aug 22.
7
Pharmacological Profiling of a Brugia malayi Muscarinic Acetylcholine Receptor as a Putative Antiparasitic Target.布氏冈比亚按蚊毒蕈碱型乙酰胆碱受体的药理学特性分析及其作为潜在抗寄生虫靶点的研究。
Antimicrob Agents Chemother. 2023 Jan 24;67(1):e0118822. doi: 10.1128/aac.01188-22. Epub 2023 Jan 5.
8
Reconstitution of an N-AChR from Brugia malayi, an evolved change in acetylcholine receptor accessory protein requirements in filarial parasites.从曼氏血吸虫中重建 N-乙酰胆碱受体，丝虫寄生虫乙酰胆碱受体辅助蛋白需求的进化变化。
PLoS Pathog. 2022 Nov 14;18(11):e1010962. doi: 10.1371/journal.ppat.1010962. eCollection 2022 Nov.
9
Allele specific PCR for a major marker of levamisole resistance in Haemonchus contortus.针对捻转血矛线虫主要左旋咪唑抗性标记物的等位基因特异性 PCR。
Int J Parasitol Drugs Drug Resist. 2022 Dec;20:17-26. doi: 10.1016/j.ijpddr.2022.08.001. Epub 2022 Aug 10.
10
Microwave Induced Green Synthesis: Sustainable Technology for Efficient Development of Bioactive Pyrimidine Scaffolds.微波诱导绿色合成：用于高效开发生物活性嘧啶支架的可持续技术
Curr Med Chem. 2023;30(9):1029-1059. doi: 10.2174/0929867329666220622150013.
本文引用的文献
1
INFLUENCE OF SOME IONS ON THE MEMBRANE POTENTIAL OF ASCARIS MUSCLE.某些离子对蛔虫肌肉膜电位的影响
J Gen Physiol. 1964 Sep;48(1):129-40. doi: 10.1085/jgp.48.1.129.
2
INHIBITION AND NEUROMUSCULAR PARALYSIS IN ASCARIS LUMBRICOIDES.蛔虫的抑制作用与神经肌肉麻痹
J Physiol. 1963 Oct;168(4):857-71. doi: 10.1113/jphysiol.1963.sp007227.
3
ELECTROPHYSIOLOGY OF THE SOMATIC MUSCLE CELLS OF ASCARIS LUMBRICOIDES.蛔虫体肌细胞的电生理学
J Cell Comp Physiol. 1963 Oct;62:159-77. doi: 10.1159/000007808.
4
Activation of the contractile mechanism in striated muscle.横纹肌收缩机制的激活。
Acta Physiol Scand. 1958 Oct 28;44(1):55-66. doi: 10.1111/j.1748-1716.1958.tb01608.x.
5
Effects of drugs on depolarized plain muscle.药物对去极化平滑肌的作用。
J Physiol. 1958 Oct 31;143(3):474-85. doi: 10.1113/jphysiol.1958.sp006072.
6
A method for recording the effects of anthelmintics on the movements of Ascaris lumbricoides.一种记录驱虫药对蛔虫运动影响的方法。
Br J Pharmacol Chemother. 1958 Jun;13(2):197-201. doi: 10.1111/j.1476-5381.1958.tb00217.x.
7
Tetramisole (R 8299), a new, potent broad spectrum anthelmintic.四咪唑（R 8299），一种新型高效广谱驱虫药。
Nature. 1966 Mar 12;209(5028):1084-6. doi: 10.1038/2091084a0.
8
[Treatment of ascariasis with tetramisole].[用四咪唑治疗蛔虫病]
Rev Inst Med Trop Sao Paulo. 1968 Mar-Apr;10(2):109-12.
9
The action of caffeine on the activation of the contractile mechanism in straited muscle fibres.咖啡因对横纹肌纤维收缩机制激活的作用。
J Physiol. 1968 Jan;194(1):51-74. doi: 10.1113/jphysiol.1968.sp008394.
Zotero 插件