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射频导管消融治疗有症状室上性快速心律失常的成本效益

Cost effectiveness of radiofrequency catheter ablation in the treatment of symptomatic supraventricular tachyarrhythmias.

作者信息

Kertes P J, Kalman J M, Tonkin A M

机构信息

Department of Cardiology, Austin Hospital Melbourne, Vic., Heidelberg.

出版信息

Aust N Z J Med. 1993 Aug;23(4):433-6. doi: 10.1111/j.1445-5994.1993.tb01458.x.

Abstract

BACKGROUND

The recent advent of radiofrequency (RF) catheter ablation as a curative therapy for supraventricular tachyarrhythmias has challenged the role of long term drug treatment, which is essentially a palliative therapy. To date, however, no data have been published on the cost-effectiveness of RF ablation as compared with drug treatment in the Australian setting.

AIMS

The study aimed to compare actual and projected costs of these two treatment options in a consecutive group of patients having RF ablation as treatment for symptomatic tachyarrhythmias.

METHODS

The cost effectiveness of RF catheter ablation was assessed in 26 patients having RF ablation, using a hypothetical model of continued drug therapy in the same group of patients. A 'cost saving' criterion was used for cost effectiveness. Actual costs for the RF ablation and for continued drug therapy were based on data from medical records and from the answers to a detailed patient questionnaire. Analysis included costs of prior diagnostic electrophysiology (EP) study (17/26 patients), general anaesthesia (GA: 20/26 patients), post-ablation echocardiography (10/26 patients), and late follow-up EP study (7/26 patients). The in-hospital stay for the RF ablation was two days in all cases, and no patient required implantation of a permanent pacemaker. The RF ablation procedure was successful in 23/26 patients (88.5%) with late recurrence of tachycardia in one patient. After a median follow-up of nine months, 22/26 patients no longer require antiarrhythmic drug therapy.

RESULTS

The mean per patient cost of RF ablation was $4067 in the study group. This reduces to $2546 if prior EP study and GA are excluded. The mean per patient cost of continued medical therapy was $700 per year. Extrapolating over 20 years and allowing for an annual 5% inflation factor, RF ablation becomes cost saving in 5.5 years (3.8 years if prior EP and GA are excluded). Over 20 years, continued drug therapy would be four to five times more expensive than RF ablation in the patient study group. We consider RF ablation to be a cost-effective alternative to long term drug therapy in patients with supraventricular tachyarrhythmias.

摘要

背景

射频(RF)导管消融术作为室上性快速心律失常的一种根治性治疗方法的出现,对长期药物治疗的作用提出了挑战,长期药物治疗本质上是一种姑息性治疗。然而,迄今为止,在澳大利亚的背景下,尚无关于射频消融与药物治疗相比成本效益的数据发表。

目的

本研究旨在比较连续一组接受射频消融治疗有症状快速心律失常患者的这两种治疗方案的实际成本和预计成本。

方法

采用同一组患者持续药物治疗的假设模型,对26例接受射频消融治疗的患者评估射频导管消融的成本效益。采用“成本节约”标准来评估成本效益。射频消融和持续药物治疗的实际成本基于病历数据和详细患者问卷的答案。分析包括先前诊断性电生理(EP)研究(17/26例患者)、全身麻醉(GA:20/26例患者)、消融后超声心动图(10/26例患者)和后期随访EP研究(7/26例患者)的成本。所有病例中射频消融的住院时间为两天,且无患者需要植入永久性起搏器。23/26例患者(88.5%)的射频消融手术成功,1例患者出现心动过速晚期复发。中位随访9个月后,22/26例患者不再需要抗心律失常药物治疗。

结果

研究组中每位患者射频消融的平均成本为4067美元。如果排除先前的EP研究和GA,这一成本降至2546美元。持续药物治疗的每位患者平均成本为每年700美元。推算20年并考虑每年5%的通胀因素,射频消融在5.5年内变得具有成本节约效益(如果排除先前的EP和GA,则为3.8年)。在患者研究组中,20年内持续药物治疗的成本将比射频消融高四到五倍。我们认为射频消融是室上性快速心律失常患者长期药物治疗的一种具有成本效益的替代方案。

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