Blauer G, Akkawi M, Bauminger E R
Department of Biological Chemistry, Hebrew University of Jerusalem, Israel.
Biochem Pharmacol. 1993 Nov 2;46(9):1573-6. doi: 10.1016/0006-2952(93)90325-q.
Evidence for complex formation of the antimalarial drug amodiaquine (AD) with ferriprotoporphyrin IX (FP) in aqueous medium is presented, in addition to previous preliminary data. A mole ratio of one between the complex components is determined for the insoluble complex at pH 6.7-6.8. Mössbauer data obtained at pH 7-8 and at higher concentrations in the millimolar range confirm the interactions existing between the complex components. These data are considered to aid in removing previous objections to a mechanism of antimalarial action involving complexes of FP with AD and related drugs.
除了之前的初步数据外，还提供了抗疟药物阿莫地喹（AD）与高铁原卟啉IX（FP）在水介质中形成复合物的证据。对于在pH 6.7 - 6.8下的不溶性复合物，确定了复合物组分之间的摩尔比为1。在pH 7 - 8以及毫摩尔范围内更高浓度下获得的穆斯堡尔数据证实了复合物组分之间存在的相互作用。这些数据被认为有助于消除之前对涉及FP与AD及相关药物复合物的抗疟作用机制的质疑。
