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围产期药物滥用筛查:对高危地区现行做法的重新评估。

Perinatal screening for drugs of abuse: reassessment of current practice in a high-risk area.

作者信息

Schulman M, Morel M, Karmen A, Chazotte C

机构信息

Bronx Municipal Hospital Center, Albert Einstein College of Medicine, NY 10461.

出版信息

Am J Perinatol. 1993 Sep;10(5):374-7. doi: 10.1055/s-2007-994765.

DOI:10.1055/s-2007-994765
PMID:8240597
Abstract

Anonymous urine toxicology screening among parturient women during 1 month in 1990 and selective newborn testing during this and the subsequent 4-month period was done to assess prevalence of drug use among parturients in a municipal hospital in the Bronx and to assess impact of infant urine toxicology screening on discharge placement. Infant testing was performed for maternal history of drug use, poor prenatal care (5 or fewer visits), or infant symptoms. Urine was screened for cocaine, opiates, methadone, barbiturates, amphetamines, and benzodiazepines. Of 204 women screened, 9.3% were positive. Of these, 74% were positive for cocaine and 21% revealed polysubstance use. Only 28.6% of cocaine-positive mothers gave a history of use. Selective testing of 1196 newborns during this 5-month period revealed an apparent prevalence of cocaine exposure of 4.9%. Selective infant testing failed to identify 42.1% of newborns of cocaine-positive women. Social work evaluation was performed on all families and was the basis for reporting to state agencies for protective services. Only 6 of 83 drug-positive infants entered foster care, none because of positive toxicology per se. Selective infant toxicology studies miss many cocaine-exposed infants and has little impact on placement. Universal social work evaluation of families may be as effective and freer of bias than selective urine screening.

摘要

1990年,对一个月内的产妇进行了匿名尿液毒理学筛查,并在此期间及随后的4个月内对新生儿进行了选择性检测,以评估布朗克斯一家市立医院中产妇的药物使用流行情况,并评估婴儿尿液毒理学筛查对出院安置的影响。对有药物使用史、产前护理差(产检次数为5次或更少)或婴儿出现症状的产妇进行婴儿检测。对尿液进行可卡因、鸦片类药物、美沙酮、巴比妥类药物、苯丙胺和苯二氮卓类药物的筛查。在接受筛查的204名女性中,9.3%呈阳性。其中,74%可卡因检测呈阳性,21%显示有多种药物使用情况。只有28.6%可卡因检测呈阳性的母亲有用药史。在此5个月期间,对1196名新生儿进行的选择性检测显示,可卡因暴露的明显患病率为4.9%。选择性婴儿检测未能识别出42.1%可卡因检测呈阳性女性的新生儿。对所有家庭进行了社会工作评估,这是向州机构报告保护性服务的依据。83名药物检测呈阳性的婴儿中只有6名进入寄养机构,没有一名是因为毒理学检测呈阳性本身。选择性婴儿毒理学研究遗漏了许多可卡因暴露婴儿,对安置影响不大。对家庭进行普遍的社会工作评估可能与选择性尿液筛查一样有效,且偏差更小。

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Perinatal screening for drugs of abuse: reassessment of current practice in a high-risk area.围产期药物滥用筛查:对高危地区现行做法的重新评估。
Am J Perinatol. 1993 Sep;10(5):374-7. doi: 10.1055/s-2007-994765.
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A comparison of meconium, maternal urine and neonatal urine for detection of maternal drug use during pregnancy.用于检测孕期母亲药物使用情况的胎粪、母体尿液和新生儿尿液的比较。
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