双萘二甲酰亚胺：一类新型抗肿瘤药物。
Bis-naphthalimides: a new class of antitumor agents.
作者信息
Braña M F, Castellano J M, Morán M, Pérez de Vega M J, Romerdahl C R, Qian X D, Bousquet P, Emling F, Schlick E, Keilhauer G
机构信息
Laboratorios Knoll S. A, Madrid, Spain.
出版信息
Anticancer Drug Des. 1993 Aug;8(4):257-68.
PMID:8240655
Abstract
A series of bis-intercalators bearing the 1,8-naphthalimide chromophore has been synthesized and in vitro activities determined. Most compounds have higher activities in HT-29 than the leader compounds Mitonafide and Amonafide. One of them (22) was selected for in vivo studies and presents an interesting activity in MX-1 and OVCAR models. (22) also acts as antitopoisomerase II.
摘要
已合成了一系列带有1,8-萘二甲酰亚胺发色团的双嵌入剂，并测定了其体外活性。大多数化合物在HT-29细胞中的活性高于先导化合物米托萘腙和氨萘非特。其中一种化合物（22）被选用于体内研究，在MX-1和OVCAR模型中表现出有趣的活性。（22）还具有抗拓扑异构酶II的作用。
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