Süsal C, Hoffman G W, Daniel V, Grant M, Opelz G
Department of Transplantation Immunology, University of Heidelberg, Germany.
J Autoimmun. 1993 Oct;6(5):601-10. doi: 10.1006/jaut.1993.1049.
The contribution of autoimmune phenomena to the development of AIDS is not fully understood. In this paper we provide new evidence that idiotypic network interactions are operative in the development of AIDS. We furthermore present a model that involves two groups of antibodies and other molecules that are related to each other by a network of specific complementarities. We define Group I molecules to include antibodies and other molecules that have direct or indirect similarities with class I MHC molecules, and Group II substances that have similarities with class II MHC. We observe an inverse relationship between Group I antibodies (including anti-Fab) and Group II antibodies (including anti-anti-gp120, anti-anti-CD8 and anti-rCD4). The potential roles of members of these two groups in AIDS pathogenesis and/or protection are discussed.
自身免疫现象对艾滋病发展的作用尚未完全明了。在本文中，我们提供了新的证据，表明独特型网络相互作用在艾滋病发展过程中发挥作用。此外，我们提出了一个模型，该模型涉及两组通过特定互补性网络相互关联的抗体和其他分子。我们将第一组分子定义为包括与I类MHC分子有直接或间接相似性的抗体和其他分子，将第二组物质定义为与II类MHC有相似性的物质。我们观察到第一组抗体（包括抗Fab）和第二组抗体（包括抗抗gp120、抗抗CD8和抗rCD4）之间呈负相关。文中讨论了这两组成员在艾滋病发病机制和/或保护中的潜在作用。
