艾滋病免疫发病机制的独特型网络模型。
An idiotypic network model of AIDS immunopathogenesis.
作者信息
Hoffmann G W, Kion T A, Grant M D
机构信息
Department of Microbiology, University of British Columbia, Vancouver, Canada.
出版信息
Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3060-4. doi: 10.1073/pnas.88.8.3060.
Considerations from a network theory of the immune system suggest that human immunodeficiency virus and allogeneic stimuli may act synergistically to cause AIDS. The immune responses to these stimuli include two components that are directed against each other. In some AIDS risk groups other antigens that mimic major histocompatibility complex antigens may substitute for allogeneic stimuli. Implications for the prevention of AIDS are discussed.
免疫系统网络理论的相关思考表明，人类免疫缺陷病毒和同种异体刺激可能协同作用导致艾滋病。对这些刺激的免疫反应包括两个相互对抗的成分。在一些艾滋病风险群体中，其他模拟主要组织相容性复合体抗原的抗原可能替代同种异体刺激。文中讨论了对艾滋病预防的启示。
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