Hansen T P, Sørensen B
Department of Pathology, Odense University Hospital, Denmark.
APMIS. 1993 Sep;101(9):663-6. doi: 10.1111/j.1699-0463.1993.tb00162.x.
A case of Sertoli-Leydig cell tumour of the ovary causing virilization in a postmenopausal woman is presented. The patient had increasing facial hair growth, deepening of the voice, a dull pain in the lower part of the abdomen and enlargement of the clitoris. Laboratory investigations showed an elevated level of plasma testosterone. Considering an ovarian tumour the most likely cause of the above-mentioned findings, hysterectomy with bilateral salpingo-oophorectomy was performed. Both ovaries were macroscopically normal at operation, but pathological examination revealed a small well-differentiated Sertoli-Leydig cell tumour in the left ovary. Follow-up 3 months later showed decreasing signs of virilization and normalization of the hormone levels.
本文报告一例绝经后女性卵巢支持-间质细胞瘤导致男性化的病例。患者面部毛发增多、声音变粗、下腹部隐痛及阴蒂增大。实验室检查显示血浆睾酮水平升高。考虑到卵巢肿瘤是上述表现最可能的原因，遂行子宫切除术及双侧输卵管卵巢切除术。术中见双侧卵巢外观正常，但病理检查发现左侧卵巢有一个小的高分化支持-间质细胞瘤。3个月后的随访显示男性化体征减轻，激素水平恢复正常。
