Zabielski R, Onaga T, Mineo H, Kato S
Department of Animal Physiology, Faculty of Veterinary Medicine, Warsaw Agricultural University, Poland.
Exp Physiol. 1993 Sep;78(5):675-84. doi: 10.1113/expphysiol.1993.sp003715.
To clarify the relative timing of clinical changes in duodenal motility and pancreatic secretion in newborn calves, we recorded duodenal electrical and mechanical activity and analysed pancreatic secretion and migrating myoelectric complex (MMC). In eight calves integrated recordings were derived from sites near the duodenal bulb and pancreatic accessory duct orifice, and pancreatic juice was sampled after an overnight fast, after a feed, and during reversible cold vagal blockade. Peak secretion coincided with duodenal irregular spiking activity and the nadir with absence of spiking. Feeding elicited electrical and mechanical hyperactivity in the duodenum, dissipated the MMC temporarily, and dramatically increased the juice volume and bicarbonate and protein outputs. Periodic fluctuations in secretion started shortly after a feed, as did recovery of the duodenal myoelectric complexes. Cold vagal blockade reversibly disrupted the synchronous changes in duodenal motility and pancreatic secretory activity, though the close association was not totally obliterated. In milk-fed calves interdigestive pancreatic secretion apparently rises and falls in phase with migrating myoelectric complexes of the proximal duodenum and the vagus is largely, though not exclusively, responsible for co-ordinating these changes.
为了阐明新生犊牛十二指肠运动和胰腺分泌临床变化的相对时间，我们记录了十二指肠的电活动和机械活动，并分析了胰腺分泌和移行性复合肌电（MMC）。在八头犊牛中，从十二指肠球部和胰腺副导管开口附近的部位进行综合记录，并在禁食过夜后、进食后以及可逆性冷迷走神经阻滞期间采集胰液样本。分泌高峰与十二指肠不规则的尖峰活动同时出现，分泌低谷则与无尖峰活动同时出现。进食引起十二指肠电活动和机械活动亢进，暂时消散MMC，并显著增加胰液量、碳酸氢盐和蛋白质分泌量。进食后不久，分泌开始出现周期性波动，十二指肠肌电复合波也开始恢复。冷迷走神经阻滞可逆地破坏了十二指肠运动和胰腺分泌活动的同步变化，尽管这种密切关联并未完全消除。在以牛奶为食的犊牛中，消化间期胰腺分泌显然与十二指肠近端的移行性复合肌电同步升降，迷走神经在很大程度上（尽管不是唯一地）负责协调这些变化。
