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The effect of oxine-5-sulphonic acid on the hepatic drug metabolism in the rat.

作者信息

Manzo L, Passoni R, Segre A D, Berte F, Crema A

出版信息

Experientia. 1976 Oct 15;32(10):1318-20. doi: 10.1007/BF01953115.

DOI:10.1007/BF01953115
PMID:824156
Abstract

Oxine-5-sulphonic acid inhibits the metabolism of aminopyrine in the rat liver in vitro. The characteristics of this inhibition vary according to whether the oxidative N-demethylation of the substrate is determined by the formation of the metabolite 4-aminoantipyrine or by the production of formaldehyde.

摘要

相似文献

1
The effect of oxine-5-sulphonic acid on the hepatic drug metabolism in the rat.
Experientia. 1976 Oct 15;32(10):1318-20. doi: 10.1007/BF01953115.
2
Inhibition of hepatic microsomal monooxygenase activity by oxine-5-sulfonic acid administered orally in rabbits.口服8-羟基喹啉-5-磺酸对兔肝微粒体单加氧酶活性的抑制作用。
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3
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5
[Characteristics of induced aminopyrine N-demethylase].
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Inhibition of rat hepatic microsomal aminopyrine N-demethylase activity by benzimidazole derivatives. Quantitative structure-activity relationships.苯并咪唑衍生物对大鼠肝微粒体氨基比林N-脱甲基酶活性的抑制作用。定量构效关系。
J Med Chem. 1982 Aug;25(8):887-92. doi: 10.1021/jm00350a002.

引用本文的文献

1
Aminopyrine: metabolism and effects in the rat after administration of inhibitors of hepatic monooxygenases.
Eur J Drug Metab Pharmacokinet. 1979;4(3):179-83. doi: 10.1007/BF03189422.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Enzymatic dealkylation of aminopyrine (pyramidon) and other alkylamines.氨基比林（匹拉米洞）及其他烷基胺的酶促脱烷基作用。
J Biol Chem. 1955 Jun;214(2):741-5.
3
Biochemical and pharmacological changes in the rat following chronic administration of morphine nalorphine and normorphine.大鼠长期给予吗啡、烯丙吗啡和去甲吗啡后的生化及药理变化。
J Pharmacol Exp Ther. 1959 Feb;125(2):105-10.
4
The rate-limiting step in the biliary elimination of some substrates of uridine diphosphate glucuronyltransferase in the rat.大鼠中尿苷二磷酸葡萄糖醛酸基转移酶某些底物经胆汁消除的限速步骤。
Biochem Pharmacol. 1973 Jul 15;22(14):1751-63. doi: 10.1016/0006-2952(73)90389-4.
5
[Skin absorption of ortho-oxyquinolinsulfate of aminophenazone].[氨基比林硫酸邻氨基酚喹啉的皮肤吸收]
Boll Chim Farm. 1974 Sep;113(9):495-502.
6
Some characteristics of hepatic microsomal systems which metabolize aminopyrine in the rat and rabbit.大鼠和家兔体内代谢氨基比林的肝微粒体系统的一些特性。
J Pharmacol Exp Ther. 1968 Jan;159(1):172-81.
7
[Clinical research on the therapeutic use of orthoxyquinoline sulfonate of dimethyl-diphenyl-amino-isopyrazolone in association with vitamins B 6 and B 12].
Minerva Med. 1967 Mar 3;58(18 Suppl):727-45.
8
Inhibition of some rat hepatic microsomal enzymes by ethoxyquin.乙氧喹对大鼠肝脏微粒体某些酶的抑制作用。
Biochem Pharmacol. 1974 Dec 15;23(24):3385-94. doi: 10.1016/0006-2952(74)90341-4.