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Some characteristics of hepatic microsomal systems which metabolize aminopyrine in the rat and rabbit.

作者信息

Gram T E, Wilson J T, Fouts J R

出版信息

J Pharmacol Exp Ther. 1968 Jan;159(1):172-81.

PMID:4384514
Abstract
摘要

相似文献

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Some characteristics of hepatic microsomal systems which metabolize aminopyrine in the rat and rabbit.大鼠和家兔体内代谢氨基比林的肝微粒体系统的一些特性。
J Pharmacol Exp Ther. 1968 Jan;159(1):172-81.
2
Oxidation of indene in liver microsomes.茚在肝微粒体中的氧化作用。
Mol Pharmacol. 1968 May;4(3):201-7.
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Studies on the rate of reduction of hepatic microsomal cytochrome P-450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates.
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5
On the fatty acid and hydrocarbon hydroxylation in rat liver microsomes.关于大鼠肝脏微粒体中的脂肪酸和碳氢化合物羟基化作用
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Oxidative drug metabolism in the perinatal rabbit liver and placenta. A biochemical and morphologic study.围产期兔肝脏和胎盘的氧化药物代谢。一项生化与形态学研究。
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Hydroxylation of benzphetamine and other drugs by a solubilized form of cytochrome P-450 from liver microsomes: lipid requirement for drug demethylation.
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Microsomal electron transport reactions. II. The use of reduced triphosphopyridine nucleotide and-or reduced diphosphopyridine nucleotide for the oxidative N-demethylation of aminopyrine and other drug substrates.
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Possible participation of cytochrome P-450 in cholesterol synthesis.细胞色素P - 450可能参与胆固醇合成。
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Validated HPLC determination of 4-dimethylaminoantipyrine in different suppository bases.高效液相色谱法测定不同栓剂基质中4-二甲基氨基安替比林的方法验证
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NMR-derived models of amidopyrine and its metabolites in complexes with rabbit cytochrome P450 2B4 reveal a structural mechanism of sequential N-dealkylation.NMR 衍生的氨比林及其代谢物与兔细胞色素 P450 2B4 复合物模型揭示了顺序 N-脱烷基化的结构机制。
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Experimental hepatobiliary injury. Comparison of in vivo drug elimination with in vitro drug-metabolizing enzyme capacity in the rat.
实验性肝胆损伤。大鼠体内药物消除与体外药物代谢酶能力的比较。
Dig Dis Sci. 1981 Jan;26(1):50-9. doi: 10.1007/BF01307975.
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Inhibition of aminopyrine demethylation and binding to cytochrome P-450 by its main metabolites in rat liver microsomes [proceedings].大鼠肝微粒体中氨基比林去甲基化的抑制及其主要代谢产物与细胞色素P-450的结合[会议论文集]
Br J Pharmacol. 1980 Jan;68(1):121P-122P.
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Pyran and polyribonucleotides: differences in biological activities.吡喃与多聚核糖核苷酸：生物活性差异
Antimicrob Agents Chemother. 1972 Jul;2(1):16-22. doi: 10.1128/AAC.2.1.16.
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Antiviral activity and side effects of polyriboinosinic-cytidylic acid complexes as affected by molecular size.多聚肌苷酸-胞苷酸复合物的抗病毒活性及副作用受分子大小的影响
Proc Natl Acad Sci U S A. 1972 Apr;69(4):842-6. doi: 10.1073/pnas.69.4.842.
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Toxicity of lead acetate to female rabbits after chronic subcutaneous administration. 1. Biochemical and clinical effects.
Arch Toxicol. 1990;64(7):522-9. doi: 10.1007/BF01971830.
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The effect of oxine-5-sulphonic acid on the hepatic drug metabolism in the rat.
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Output of 14CO2 in breath after oral administration of (14C-methyl) aminopyrine in hepatitis, cirrhosis and hepatic bilharziasis: its relationship to aminopyrine pharmacokinetics.口服（14C-甲基）氨基比林后，肝炎、肝硬化及肝血吸虫病患者呼出的14CO2：其与氨基比林药代动力学的关系
Eur J Clin Pharmacol. 1978 May 31;13(3):223-9. doi: 10.1007/BF00609987.
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Dose dependence of the 14C-aminopyrine breath test. Intrasubject comparison of tracer and pharmacological doses.14C-氨基比林呼气试验的剂量依赖性。示踪剂剂量与药理剂量的受试者内比较。
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