Ganzini L, Millar S B, Walsh J R
Psychiatry Service, Portland Veterans Affairs Medical Center, Oregon.
Drugs Aging. 1993 Sep-Oct;3(5):428-35. doi: 10.2165/00002512-199303050-00004.
Mania is a rare complication of prescribed drug use in elderly persons. The drugs most likely to produce mania include corticosteroids and dopamine agonists. It is uncertain if antidepressants cause mania or only increase the propensity for latent bipolar mania to be expressed. Drug-induced mania may promote poor judgment, risk-taking behaviours and medical noncompliance. The majority of episodes of drug-induced mania are short-lived and respond to discontinuation of the drug. Antipsychotic agents may hasten resolution of this psychiatric syndrome. Lithium may prevent corticosteroid-induced mania, but the role of lithium in the treatment of other drug-induced manic episodes has not been studied adequately.
躁狂是老年人使用处方药时罕见的并发症。最有可能引发躁狂的药物包括皮质类固醇和多巴胺激动剂。抗抑郁药是否会引发躁狂，还是仅仅增加潜在双相躁狂发作的可能性，目前尚不确定。药物性躁狂可能会导致判断力下降、冒险行为和不遵守医嘱。大多数药物性躁狂发作是短暂的，停药后会有所缓解。抗精神病药物可能会加速这种精神综合征的缓解。锂盐可能预防皮质类固醇诱发的躁狂，但锂盐在治疗其他药物性躁狂发作中的作用尚未得到充分研究。
