Ko G N, Leckman J F, Heninger G R
Am J Psychiatry. 1981 Dec;138(12):1624-5. doi: 10.1176/ajp.138.12.1624.
The authors report a longitudinal case study of a woman with a history of bipolar affective disorder in which L-dopa shortened the manic-depressive cycle length when administered in a double-blind trial. This finding suggests a dopaminergic mechanism specifically in changing the frequency of cycling between depression and mania.
作者报告了一项针对一名有双相情感障碍病史女性的纵向病例研究，在双盲试验中给予左旋多巴时，其缩短了躁狂 - 抑郁周期的时长。这一发现提示了一种多巴胺能机制，特别是在改变抑郁和躁狂之间的循环频率方面。
