Okisaka S
Invest Ophthalmol. 1976 Oct;15(10):824-34.
The effects of paracentesis on the blood-aqueous barrier of cynomolgus monekeys were studied by light and electron microscopy. The following regions of the eye were examined: ciliary body, iris, Schlemm's canal, juxtacanalicular connective tissue, and trabecular meshwork. Prominent structural alterations were seen in the ciliary epithelium at the anterior portion of the pars plicata, but the epithelium at the posterior portion of the pars plicata and at the pars plana appeared less disrupted. Plasma proteins which crossed the capillary endothelium accumulated in the stroma, and appeared in the posterior chamber through the enlarged extracellular spaces of the ciliary epithelium. The plasma proteins in the ciliary stroma of the anterior portion of the pars plicata moved to the stroma of the iris root; whereas in the iris the capillary endothelium provide an impermeable barrier to proteins. Following paracentesis, the lumen of Schlemm's canal was invaded by blood, and through newly formed gaps in the endothelial lining of the inner wall of the canal, the plasma proteins and red blood cells rapidly diffused into the juxtacanalicular connective tissue, trabecular meshwork, and anterior chamber. On the basis of the present experiments, the protein of the aqueous humor can be considered as originating from both the anterior portion of the pars plicata and the inner wall of Schlemm's canal.
通过光学显微镜和电子显微镜研究了穿刺术对食蟹猴血-房水屏障的影响。检查了眼睛的以下区域：睫状体、虹膜、施莱姆管、管周结缔组织和小梁网。在褶部前部的睫状体上皮中可见明显的结构改变，但褶部后部和平坦部的上皮破坏较轻。穿过毛细血管内皮的血浆蛋白积聚在基质中，并通过睫状体上皮扩大的细胞外间隙出现在后房。褶部前部睫状体基质中的血浆蛋白移至虹膜根部的基质；而在虹膜中，毛细血管内皮对蛋白质提供了不透性屏障。穿刺术后，施莱姆管腔被血液侵入，血浆蛋白和红细胞通过管内壁内皮衬里新形成的间隙迅速扩散到管周结缔组织、小梁网和前房。基于本实验，房水蛋白可被认为既来源于褶部前部，也来源于施莱姆管内壁。
